Dietary Fat, Sugar Consumption, and Cardiorespiratory Fitness in Patients With Heart Failure With Preserved Ejection Fraction
| Autor: | Eleonora Mezzaroma, Justin M. Canada, Leo F. Buckley, Ross Arena, Adolfo G Mauro, Dinesh Kadariya, Benjamin W. Van Tassell, Antonio Abbate, Sofanit Dessie, Dave L. Dixon, Stefano Toldo, Cory R. Trankle, Raffaella Buzzetti, Hayley Billingsley, Salvatore Carbone |
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| Rok vydání: | 2017 |
| Předmět: |
heart failure with preserved ejection fraction
lcsh:Diseases of the circulatory (Cardiovascular) system obesity FFM fat-free mass medicine.medical_specialty CLINICAL RESEARCH SFA saturated fatty acid HFpEF heart failure with preserved ejection fraction Vo2 oxygen consumption Sugar consumption 030204 cardiovascular system & hematology HF heart failure law.invention DT deceleration time 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine PUFA polyunsaturated fatty acid MUFA monounsaturated fatty acid Medicine 030212 general & internal medicine UFA unsaturated fatty acid IQR interquartile range Dietary fat chemistry.chemical_classification body composition CRF cardiorespiratory fitness business.industry FM fat mass CV cardiovascular Cardiorespiratory fitness medicine.disease Obesity Endocrinology chemistry lcsh:RC666-701 Cardiology medicine.symptom diet Cardiology and Cardiovascular Medicine business Heart failure with preserved ejection fraction Weight gain unsaturated fatty acids CPX cardiopulmonary exercise testing Polyunsaturated fatty acid |
| Zdroj: | JACC: Basic to Translational Science JACC: Basic to Translational Science, Vol 2, Iss 5, Pp 513-525 (2017) |
| ISSN: | 2452-302X |
| DOI: | 10.1016/j.jacbts.2017.06.009 |
| Popis: | Visual Abstract Highlights • The effects of UFA on CRF in patients with HFpEF are unknown. • In obese HFpEF patients, UFA consumption analyzed with a validated 24-h dietary recall was positively associated with improved body composition, cardiac diastolic function and greater CRF, measured as peak VO2 at maximal cardiopulmonary exercise testing. Conversely, sugars consumption was associated with worse CRF. • In mice, an isocaloric high-fat diet, high in UFA and low in saturated fat prevented cardiac diastolic dysfunction measured with echocardiography and body weight gain in a model of cardiac dysfunction and obesity induced by Western diet, despite similar total caloric intake. • A high-UFA diet is associated with preservation of CRF in patients with HFpEF and cardiac function in the mouse. Summary Heart failure with preserved ejection fraction (HFpEF) is associated with obesity and, indirectly, with unhealthy diet. The role of dietary components in HFpEF is, however, largely unknown. In this study, the authors showed that in obese HFpEF patients, consumption of unsaturated fatty acids (UFA), was associated with better cardiorespiratory fitness, and UFA consumption correlated with better diastolic function and with greater fat-free mass. Similarly, mice fed with a high-fat diet rich in UFA and low in sugars had preserved myocardial function and reduced weight gain. Randomized clinical trials increasing dietary UFA consumption and reducing sugar consumption are warranted to confirm and expand our findings. |
| Databáze: | OpenAIRE |
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