Functionality of the pneumococcal antibody response in Down syndrome subjects
| Autor: | B A W de Jong, Maaike A A Kusters, E. de Vries, N C C Manders, R.W.N.M. van Hout, Ger T. Rijkers |
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| Rok vydání: | 2013 |
| Předmět: |
Serotype
Adult Male Down syndrome Adolescent Specific anti-polysaccharide antibody deficiency niet-RU-publicaties Pneumococcal Vaccines Young Adult Phagocytosis medicine Heptavalent Pneumococcal Conjugate Vaccine Humans Child Aged Aged 80 and over General Veterinary General Immunology and Microbiology biology business.industry Common variable immunodeficiency Polysaccharides Bacterial Public Health Environmental and Occupational Health Antibody titer Middle Aged Opsonin Proteins medicine.disease Antibodies Bacterial Titer Infectious Diseases Immunology biology.protein Molecular Medicine Female Antibody Down Syndrome business |
| Zdroj: | Vaccine, 31, 6261-6265 Vaccine, 31, 52, pp. 6261-6265 |
| ISSN: | 1873-2518 0264-410X |
| Popis: | We investigated the anti-polysaccharide antibody responses in subjects with Down syndrome (DS) because DS subjects show decreased peripheral B-lymphocyte numbers in all age groups, and a clinical picture of recurrent respiratory tract infections and increased incidence of autoimmune diseases which is reminiscent of common variable immunodeficiency disorders (CVID)-like disease. We determined titers and opsonophagocytosis in response to conjugated and unconjugated pneumococcal serotypes in 18 DS subjects aged 6–24 years. The results show adequate serotype-specific antibody titers in response to all conjugated and almost all unconjugated serotypes used. Opsonophagocytosis activity as measured against pneumococcal serotypes 9N, 19F and 23F was also found to be intact. We conclude that DS subjects do not have a clear defect in their anti-polysaccharide antibody response. |
| Databáze: | OpenAIRE |
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