Small RNAs in the control of RpoS, CsgD, and biofilm architecture ofEscherichia coli
| Autor: | Franziska Mika, Regine Hengge |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
ArcZ
Regulator Sigma Factor Review Biology curli medicine.disease_cause biofilm Hfq RprA Microbiology chemistry.chemical_compound RpoS Bacterial Proteins Sigma factor RNA polymerase Escherichia coli medicine RNA Antisense Base Pairing Molecular Biology Transcription factor Messenger RNA Binding Sites CsgD Escherichia coli Proteins McaS Biofilm c-di-GMP Gene Expression Regulation Bacterial Cell Biology cellulose Cell biology Oxidative Stress RNA Bacterial chemistry Biofilms Trans-Activators RNA Small Untranslated Gene-Environment Interaction rpoS |
| Zdroj: | RNA Biology |
| ISSN: | 1555-8584 1547-6286 |
| DOI: | 10.4161/rna.28867 |
| Popis: | Amyloid curli fibers and cellulose are extracellular matrix components produced in the stationary phase top layer of E. coli macrocolonies, which confer physical protection, strong cohesion, elasticity, and wrinkled morphology to these biofilms. Curli and cellulose synthesis is controlled by a three-level transcription factor (TF) cascade with the RpoS sigma subunit of RNA polymerase at the top, the MerR-like TF MlrA, and the biofilm regulator CsgD, with two c-di-GMP control modules acting as key switching devices. Additional signal input and fine-tuning is provided by an entire series of small RNAs-ArcZ, DsrA, RprA, McaS, OmrA/OmrB, GcvB, and RydC--that differentially control all three TF modules by direct mRNA interaction. This review not only summarizes the mechanisms of action of these sRNAs, but also addresses the question of how these sRNAs and the regulators they target contribute to building the intriguing three-dimensional microarchitecture and macromorphology of these biofilms. |
| Databáze: | OpenAIRE |
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