| Autor: |
Matthew A Warner, Ronald S Go, Phillip J Schulte, William B Beam, Jonathan E Charnin, Laurie Meade, Kim A Droege, Brenda K Anderson, Matthew L Johnson, Brad Karon, Andrea Cheville, Ognjen Gajic, Daryl J Kor |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
BMJ open. 12(12) |
| ISSN: |
2044-6055 |
| Popis: |
IntroductionAnaemia is highly prevalent in critical illness and is associated with impaired outcomes during and after hospitalisation. However, the impact of interventions designed to attenuate or treat anaemia during critical illness on post-hospitalisation haemoglobin recovery and functional outcomes is unclear.Methods and analysisThe Practical Anemia Bundle for Sustained Blood Recovery (PABST-BR) clinical trial is a pragmatic, open-label, parallel group, single-centre, randomised clinical trial assessing the impact of a multifaceted anaemia prevention and treatment strategy versus standard care for improvement of haemoglobin concentrations and functional outcomes after critical illness. The intervention, which will be delivered early in critical illness for those with moderate-to-severe anaemia (ie, haemoglobin Ethics and disseminationThe study has been approved by the Institutional Review Board of the Mayo Clinic in Minnesota, USA. A Data Safety Monitoring Plan has been created in accordance with the policies of the Institutional Review Board and the study funder, the National Heart, Lung and Blood Institute of the National Institutes of Health (NIH). The study will comply with NIH data sharing and dissemination policies. Results will be presented at national and international meetings and published in peer-reviewed journals. Designing and testing strategies to optimise haemoglobin recovery and improve functional outcomes after critical illness remain important research gaps. The PABST-BR trial will inform the development of a larger multicentre clinical trial.Trial registration numberNCT05167734. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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