Immunotherapy of metastatic kidney cancer
| Autor: | Stefano Boriani, Caterina De Vinci, Giuseppe L. O. Conte, Ennio Dragoni, Tiziano Bergami, L. Busutti, Vittorio Fornarola, Rodolfo Capanna, G. Pizza, Ernesto Aiello, Paolo Maver, A. Palareti |
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| Rok vydání: | 2001 |
| Předmět: |
transfer factor
Adult Male Cancer Research medicine.medical_specialty Lung Neoplasms Adolescent Lymphocyte medicine.medical_treatment renal cancer Gastroenterology Immunotherapy Adoptive Metastasis Thromboplastin Quality of life Multicenter trial Internal medicine Medicine metastasis Humans immunotherapy IL-2 lymphokine-act ivated killer cells interferon Adverse effect Aged Aged 80 and over Inhalation business.industry Immunotherapy Middle Aged medicine.disease Kidney Neoplasms Surgery Killer Cells Natural medicine.anatomical_structure Oncology Interleukin-2 Female Interferons business Kidney disease |
| Zdroj: | International journal of cancer. 94(1) |
| ISSN: | 0020-7136 |
| Popis: | From April 1986 to September 2000, 122 MRCC patients were treated by monthly intralymphatic injections (containing a mean of 573 IL-2 U and 26 × 106 LAK cells) and i.m. administration of IFN and TF; 71 patients also received a 3-day cycle of monthly IL-2 inhalations with a mean of 998 daily U. MRCC cases not treated by immunotherapy (n = 89) represent our historical controls. Adverse clinical side effects related to treatment were negligible. CR (n = 11) and PR (n = 13) were noticed in 24/122 patients. Of 24 responding patients, 17 resumed progression, whereas 7 remain in remission 11–69 months later. The overall median survival of treated patients (28 months) was 3.5-fold higher than the median survival of historical controls (7.5 months), and a Kaplan-Meier curve showed 25% survival 11 years after the beginning of immunotherapy. Apparently, the addition of IL-2 by inhalation improved survival. The present immunotherapy protocol appears to be efficacious, safe, devoid of adverse side effects, far less costly than others and able to offer a good quality of life to MRCC patients; if confirmed in a multicenter trial, it could set the basis for developing low-dose immunomodulatory treatments. © 2001 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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