Effects of individualized exercise training in patients with catecholaminergic polymorphic ventricular tachycardia type 1
| Autor: | Ravinea Manotheepan, Tore K. Danielsen, Kristina H. Haugaa, Thor Edvardsen, Mathis K. Stokke, Jørg Saberniak, Ivar Sjaastad |
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| Rok vydání: | 2013 |
| Předmět: |
Tachycardia
Adult Male medicine.medical_specialty Adolescent DNA Mutational Analysis Catecholaminergic polymorphic ventricular tachycardia Young Adult Heart Rate Internal medicine Heart rate Medicine Humans Genetic Predisposition to Disease Adverse effect computer.programming_language Exercise Tolerance medicine.diagnostic_test business.industry sed VO2 max Ryanodine Receptor Calcium Release Channel DNA Middle Aged medicine.disease Exercise Therapy Ambulatory Mutation Cardiology Electrocardiography Ambulatory Exercise Test Tachycardia Ventricular Female medicine.symptom Cardiology and Cardiovascular Medicine business computer Electrocardiography Follow-Up Studies |
| Zdroj: | The American journal of cardiology. 113(11) |
| ISSN: | 1879-1913 |
| Popis: | Ventricular arrhythmias (VAs) in patients with catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) are triggered at an individual and reproducible heart rate (HR) during exercise. Long-term effects of exercise on arrhythmia threshold in CPVT1 are not known. To investigate whether exercise training (ET) is feasible in patients with CPVT1, 13 patients with CPVT1 and confirmed genetic mutations performed bicycle exercise testing with maximal oxygen uptake (VO2max) measurements at baseline and after 13 weeks. The threshold HR for VA was defined as the HR when bigeminal ventricular extrasystoles or more severe VAs occurred. Six patients were enrolled in a 12-week high-intensity ergometer bicycle ET program (ET patients) with 60 min exercise sessions 3 times per week. The remaining 7 patients with CPVT1 were included as "sedentary" control (SED) patients complying with current recommendations to restrain from high-intensity physical activity. ET patients completed 28 ± 3 exercise sessions (78 ± 8% program completion) with 13 ± 3% increase in VO2max versus baseline (20.2 ± 1.6 vs 17.9 ± 1.3 ml/kg/min, p |
| Databáze: | OpenAIRE |
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