BMP-2 and asporin expression regulate 5-aza-dC-mediated osteoblast/cementoblast differentiation of periodontal dental ligament mesenchymal progenitor cells

Autor:	Catharina Marques Sacramento, Rahyza Inácio Freire Assis, Miki Taketomi Saito, Ricardo Della Coletta, Mauricio da Rocha Dourado, Enilson A. Sallum, Francisco H. Nociti, Renato Correa Viana Casarin, Denise Carleto Andia, Karina Gonzales Silvério
Rok vydání:	2021
Předmět:	Dental Cementum Cancer Research Ligaments Osteoblasts Periodontal Ligament Osteocalcin Bone Morphogenetic Protein 2 Cell Differentiation Core Binding Factor Alpha 1 Subunit Mesenchymal Stem Cells Cell Biology Alkaline Phosphatase Azacitidine Molecular Biology Developmental Biology
Zdroj:	Differentiation; research in biological diversity. 124
ISSN:	1432-0436
Popis:	Periodontal dental ligament (PDL) is composed of heterogeneous population of mesenchymal progenitor cells. The mechanisms that regulate the differentiation of these cells towards osteoblast/cementoblast phenotype are not fully understood. Some studies have demonstrated that is possible to change the pattern of cell differentiation via epigenetic mechanisms. The proposal of this study was to investigate whether 5-aza-2'-deoxycytidine (5-aza-dC) treatment would stimulate the osteoblast/cementoblast differentiation of periodontal ligament mesenchymal progenitor cells (PDL-CD105
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e03932d51d67480270300cda3e49b4d https://pubmed.ncbi.nlm.nih.gov/35151064 Zobrazit plný text záznamu Full Text from ScienceDirect