Effect of Selenium Nanoparticle Supplementation on Tissue Inflammation, Blood Cell Count, and IGF-1 Levels in Spinal Cord Injury-Induced Rats

Autor: Moosa Javdani, Atefeh Habibi, Farzaneh Hosseini, Gholam Ali Kojouri, Sadegh Shirian
Rok vydání: 2018
Předmět:
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Lymphocyte
Clinical Biochemistry
Administration
Oral
chemistry.chemical_element
Inflammation
010501 environmental sciences
01 natural sciences
Biochemistry
Neuroprotection
Inorganic Chemistry
Blood cell
Selenium
03 medical and health sciences
Oral administration
Internal medicine
medicine
Animals
Insulin-Like Growth Factor I
Spinal cord injury
Spinal Cord Injuries
0105 earth and related environmental sciences
0303 health sciences
business.industry
Monocyte
030302 biochemistry & molecular biology
Biochemistry (medical)
General Medicine
medicine.disease
Blood Cell Count
Rats
Disease Models
Animal
Neuroprotective Agents
medicine.anatomical_structure
Endocrinology
chemistry
Dietary Supplements
Nanoparticles
Female
medicine.symptom
business
Zdroj: Biological Trace Element Research. 187:202-211
ISSN: 1559-0720
0163-4984
Popis: Selenium is known to be a neuroprotective agent in respect to a number of neuronal diseases and pain. The aim of this study was to evaluate the neuroprotective effect of the oral administration of selenium nanoparticles in rats with spinal cord injury (SCI). Forty adult female rats were randomly assigned to two equal groups as experimental and control. Under general inhalation anesthesia, in both groups, SCI was created, at the T9-10 level of the column. On the third day after the operation, a supplement of selenium nanoparticle was administered to the experimental group at 0.2 mg/kg per day. The histology of the site of injury, IGF-1 serum concentrations, and changes in the white blood cells were examined in both groups at different pre-surgical and post-surgical times. The results of the current study showed a significant decrease in the total white blood cells, including lymphocyte, neutrophil, and monocyte in the experimental group compared to the control group. Histological evaluation showed that the inflammatory responses reduced significantly in the experimental group compared to the control group. In conclusion, we speculate that the decrease in the number of inflammatory cells after oral administration of the selenium nanoparticles is due to the neuroprotective effects of this nanoparticle.
Databáze: OpenAIRE
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