Glucagon-Like Peptide-1 Analog Liraglutide Attenuates Pressure-Overload Induced Cardiac Hypertrophy and Apoptosis through Activating ATP Sensitive Potassium Channels
| Autor: | Xiao-Jie Bai, Cai-Hong Yang, Wei-Fang Zhang, Jun-Tao Hao, Zhi-Qing Zhao, Cai-Ping Yan, Rong-Hua Zheng, Jin Wang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cardiac function curve Male medicine.medical_specialty Hemodynamics Apoptosis Cardiomegaly 030204 cardiovascular system & hematology Glibenclamide Rats Sprague-Dawley 03 medical and health sciences Random Allocation 0302 clinical medicine KATP Channels Glucagon-Like Peptide 1 Internal medicine Glyburide medicine Animals Pharmacology (medical) Pharmacology Pressure overload Ejection fraction business.industry Liraglutide General Medicine medicine.disease Potassium channel Rats 030104 developmental biology Endocrinology Heart failure Drug Therapy Combination Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiovascular drugs and therapy. 35(1) |
| ISSN: | 1573-7241 |
| Popis: | This study aimed to investigate whether inhibition of glucagon-like peptide-1 (GLP-1) on pressure overload induced cardiac hypertrophy and apoptosis is related to activation of ATP sensitive potassium (KATP) channels. Male SD rats were randomly divided into five groups: sham, control (abdominal aortic constriction), GLP-1 analog liraglutide (0.3 mg/kg/twice day), KATP channel blocker glibenclamide (5 mg/kg/day), and liraglutide plus glibenclamide. Relative to the control on week 16, liraglutide upregulated protein and mRNA levels of KATP channel subunits Kir6.2/SUR2 and their expression in the myocardium, vascular smooth muscle, aortic endothelium, and cardiac microvasculature. Consistent with a reduction in aortic wall thickness (61.4 ± 7.6 vs. 75.0 ± 7.6 μm, p |
| Databáze: | OpenAIRE |
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