3D-Printed Coronary Implants Are Effective for Percutaneous Creation of Swine Models with Focal Coronary Stenosis

Autor: John J Hollowed, Gregory A. Fishbein, Peng Hu, Sandra Duarte-Vogel, Caroline M Colbert, Rohan Dharmakumar, Jiaxin Shao, Jesse Currier, Kim-Lien Nguyen, Olujimi A. Ajijola
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Sus scrofa
Myocardial Infarction
Pharmaceutical Science
Infarction
030204 cardiovascular system & hematology
Cardiovascular
Coronary artery disease
0302 clinical medicine
Myocardial infarction
Genetics (clinical)
Cardiac imaging
screening and diagnosis
medicine.diagnostic_test
Myocardial Perfusion Imaging
3D printing
Magnetic Resonance Imaging
Detection
Heart Disease
Cine
Printing
Three-Dimensional
Molecular Medicine
Printing
Biomedical Imaging
Radiology
Cardiology and Cardiovascular Medicine
MRI
4.2 Evaluation of markers and technologies
medicine.medical_specialty
Ischemic heart disease
Stress testing
Ischemia
Magnetic Resonance Imaging
Cine
Bioengineering
Prosthesis Design
Proof of Concept Study
Article
Prosthesis Implantation
03 medical and health sciences
Coronary Circulation
Genetics
medicine
Animals
Minimally invasive
Acute swine model
Heart Disease - Coronary Heart Disease
business.industry
Animal
Coronary Stenosis
Magnetic resonance imaging
medicine.disease
Atherosclerosis
4.1 Discovery and preclinical testing of markers and technologies
Stenosis
Disease Models
Animal
030104 developmental biology
Disease Models
Three-Dimensional
Feasibility Studies
Implant
business
Zdroj: J Cardiovasc Transl Res
Journal of cardiovascular translational research, vol 13, iss 6
ISSN: 1937-5395
Popis: Reliable, closed-chest methods for creating large animal models of acute myocardial hypoperfusion are limited. We demonstrated the feasibility and efficacy of using magnetic resonance (MR)-compatible 3D-printed coronary implants for establishing swine models of myocardial hypoperfusion. We designed, manufactured, and percutaneously deployed implants in 13 swine to selectively create focal coronary stenosis. To test the efficacy of the implants to cause hypoperfusion or ischemia in the perfused territory, we evaluated regional wall motion, myocardial perfusion, and infarction using MR imaging. The overall swine survival rate was 85% (11 of 13). The implant retrieval rate was 92% (12 of 13). Fluoroscopic angiography confirmed focal stenosis. Cine and perfusion MRI showed regional wall motion abnormalities and inducible ischemia, respectively. Late gadolinium enhancement and histopathology showed no myocardial infarction. Our minimally invasive technique has promising applications for validation of new diagnostic methods in cardiac MR. Graphical abstract Our new minimally invasive, percutaneous method for creating swine models of acute focal coronary stenosis can be used for magnetic resonance imaging studies of myocardial ischemia. Comparable to existing methods in its efficacy and reliability, this rapid prototyping technique will allow researchers to more easily conduct translational cardiac imaging studies of coronary artery disease in large animal models.
Databáze: OpenAIRE
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