Remifentanil infusion during emergence moderates hemodynamic and cough responses to the tracheal tube: A randomized controlled trial
| Autor: | Mohammad Reza Ghodraty, Nader D. Nader, Alireza Kholdebarin, Amirhossein Bagheri-Aghdam, Alireza Pournajafian, Valiollah Hasani, Mohammad Mahdi Zamani, Faranak Rokhtabnak |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Mean arterial pressure medicine.medical_treatment Remifentanil Tracheal tube Placebo 03 medical and health sciences Postoperative Complications 0302 clinical medicine Double-Blind Method Piperidines Heart Rate 030202 anesthesiology Heart rate Intubation Intratracheal Humans Medicine Arterial Pressure Retching Prospective Studies 030212 general & internal medicine Infusions Intravenous Saline Aged business.industry Hemodynamics Middle Aged Analgesics Opioid Anesthesiology and Pain Medicine Cough Anesthesia Anesthesia Recovery Period Female medicine.symptom business Craniotomy medicine.drug |
| Zdroj: | Journal of Clinical Anesthesia. 33:514-520 |
| ISSN: | 0952-8180 |
| DOI: | 10.1016/j.jclinane.2015.09.001 |
| Popis: | Objective To examine the severity of cough and straining at the time of emergence from anesthesia. Design Double-blind randomized, placebo-controlled study. Setting University-affiliated hospital. Patients Sixty-two American Society of Anesthesiologists 2 patients undergoing craniotomy and excision of supratentorial cerebral tumors. Intervention Intravenous infusion of remifentanil (REM) at 0.05 μg/kg/min or normal saline (NS) upon termination of the surgical procedure. Measurements Heart rate (HR) and mean arterial pressure (MAP) along with the frequency and severity of cough response (Modified Minogue Scale) to the endotracheal tube were recorded at different time points. The frequency of cough and straining was analyzed with χ 2 tests. HRs and MAP were analyzed by repeated-measures analysis of variance between REM and NS groups. Main Results There was no case of significant cough in the REM group, and all of the patients in the NS group developed some extent of cough varying from mild retching to severe coughing episodes ( P Conclusion Infusion of REM at the end of craniotomy procedures results in significant reduction of the frequency and severity of coughing and straining. Compared to placebo, REM moderates increases in MAP upon emergence from general anesthesia until the time of extubation. |
| Databáze: | OpenAIRE |
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