Extracellular matrix remodeling with stress and depression: Studies in human, rodent and zebrafish models
| Autor: | Katherine Conant, Ismary Blanco |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Rodentia
Inhibitory postsynaptic potential Article Extracellular matrix Social defeat 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Corticosterone Interneurons Animals Humans Zebrafish 030304 developmental biology 0303 health sciences biology Depression General Neuroscience Perineuronal net biology.organism_classification Extracellular Matrix Parvalbumins chemistry biology.protein Monoamine reuptake inhibitor Neuroscience 030217 neurology & neurosurgery Parvalbumin Stress Psychological |
| Zdroj: | Eur J Neurosci |
| ISSN: | 1460-9568 |
| Popis: | Emerging evidence suggests that extracellular matrix (ECM) alterations occur with stress. Specifically, increases in perineuronal net (PNN) deposition have been observed in rodents exposed to chronic corticosterone or persistent social defeat stress. The PNN is a specific form of ECM that is predominantly localized to parvalbumin (PV)-expressing inhibitory interneurons where it modulates neuronal excitability and brain oscillations that are influenced by the same. Consistent with a role for ECM changes in contributing to the depressive phenotype, recent studies have demonstrated that monoamine reuptake inhibitor type antidepressants can reduce PNN deposition, improve behavior, and stimulate changes in gamma oscillatory power that may be important to mood and memory. The present review will highlight studies in humans, rodents, and zebrafish that have examined stress, PNN deposition and/or gamma oscillations with a focus on potential cellular and molecular underpinnings. |
| Databáze: | OpenAIRE |
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