Paired comparison of bathwater versus oral delivery of 8-methoxypsoralen in psoralen plus ultraviolet A therapy for chronic palmoplantar psoriasis
| Autor: | Franz Quehenberger, Angelika Hofer, Helmut Kerl, Peter Wolf, R. Fink-Puches |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythema Nausea medicine.medical_treatment Immunology Hand Dermatoses Dermatology law.invention chemistry.chemical_compound Randomized controlled trial Oral administration law Psoriasis medicine Humans Immunology and Allergy Radiology Nuclear Medicine and imaging PUVA Therapy Psoralen Aged Foot Dermatoses Photosensitizing Agents business.industry Baths General Medicine Middle Aged medicine.disease Regimen Treatment Outcome chemistry PUVA therapy Methoxsalen Female medicine.symptom business |
| Zdroj: | Photodermatology, Photoimmunology and Photomedicine. 22:1-5 |
| ISSN: | 1600-0781 0905-4383 |
| Popis: | Background: Both bath psoralen plus ultraviolet A (PUVA) and oral PUVA with 8-methoxypsoralen (8-MOP) have been successfully used for the treatment of recalcitrant palmoplantar psoriasis. This trial was designed to assess the efficacy and side effects of the different treatment modalities in a randomized half-side comparison. Methods: Eight patients with moderate-to-severe psoriasis on soles (n=6) and/or palms (n=8) were randomly assigned to receive bath PUVA treatment on one side and oral PUVA on the other. Initial treatment dose was 50% of the minimal phototoxic dose evaluated for bath PUVA and oral PUVA. Treatment was given three times a week for 4 weeks. Before treatment and every week a severity index (SI) was assessed by summing the scores of erythema, infiltration, scaling and vesicles evaluated on a scale from 0 to 4. After 4 weeks of treatment the half-side trial was finished and the treatment was continued on both sides with the more effective treatment regimen. Results: Both bath PUVA and oral PUVA achieved a reduction of the mean initial SI from 5.9 (95% confidence intervals (CI) 4.5–8.0) to 3.3 (1.8–6.0) (44% SI reduction, P |
| Databáze: | OpenAIRE |
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