Suppression of Propionibacterium acnes-Induced Skin Inflammation by Laurus nobilis Extract and Its Major Constituent Eucalyptol
| Autor: | Eunmi Choi, Su Ryeon Seo, Eunhye Lee, Jin Hak Shin, Seon Sook Kim, Ji-Hye Joo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Anti-Inflammatory Agents
Folliculitis Inflammation Laurus nobilis L Laurus Article NF-κB Catalysis Cell Line Proinflammatory cytokine lcsh:Chemistry Inorganic Chemistry Mice Propionibacterium acnes chemistry.chemical_compound Immune system Acne Vulgaris Animals Medicine Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Gram-Positive Bacterial Infections Spectroscopy Acne integumentary system biology Plant Extracts business.industry Organic Chemistry General Medicine biology.organism_classification medicine.disease Computer Science Applications eucalyptol lcsh:Biology (General) lcsh:QD1-999 chemistry inflammation proinflammatory cytokines Immunology Anaerobic bacteria medicine.symptom business |
| Zdroj: | International Journal of Molecular Sciences Volume 20 Issue 14 International Journal of Molecular Sciences, Vol 20, Iss 14, p 3510 (2019) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms20143510 |
| Popis: | Acne is an inflammatory skin disorder in puberty with symptoms including papules, folliculitis, and nodules. Propionibacterium acnes (P. acnes) is the main anaerobic bacteria that cause acne. It is known to proliferate within sebum-blocked skin hair follicles. P. acnes activates monocytic cell immune responses to induce the expression of proinflammatory cytokines. Although the anti-inflammatory function of the Laurus nobilis (L. nobilis) extract (LNE) on several immunological disorders have been reported, the effect of LNE in P. acnes-mediated skin inflammation has not yet been explored. In the present study, we examined the ability of the LNE to modulate the P. acnes-induced inflammatory signaling pathway, and evaluated its mechanism. LNE significantly suppressed the expression of P. acnes-mediated proinflammatory cytokines, such as IL-1&beta IL-6, and NLRP3. We also found that LNE inhibited the inflammatory transcription factor NF-&kappa B in response to P. acnes. In addition, eucalyptol, which is the main constituent of LNE, consistently inhibited P. acnes-induced inflammatory signaling pathways. Moreover, LNE significantly ameliorated P. acnes-induced inflammation in a mouse model of acne. We suggest for the first time that LNE hold therapeutic value for the improvement of P. acnes-induced skin inflammation. |
| Databáze: | OpenAIRE |
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