Human ESC-derived immunity- and matrix- regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion

Autor:	Yilong Zhao, Jun Wu, Da Li, Jing Liu, Weiqi Chen, Zongren Hou, Kailun Liu, Lingling Jiang, Xiaowei Chen, Liu Wang, Baoyang Hu, Fangrong Zong, Yukai Wang, Yilong Wang
Rok vydání:	2022
Předmět:	Disease Models Animal Cognition Animals Humans Cognitive Dysfunction Cell Biology General Medicine Microglia White Matter Brain Ischemia Rats
Zdroj:	Cell proliferation. 55(5)
ISSN:	1365-2184
Popis:	This study investigated the ability of immunity- and matrix- regulatory cells (IMRCs) to improve cognitive function in a rat model of vascular cognitive impairment.A chronic cerebral hypoperfusion (CCH) model was established in rats via permanent bilateral occlusion of the common carotid arteries (two-vessel occlusion, 2VO). The rats then received intravenous injections of IMRCs or saline. A single injection of different doses of IMRCs (1 × 10Intravenous injection of 4 × 10Intravenous injection of IMRCs protected against CCH-induced white matter injury and cognitive impairment inhibition of microglial activation and regulation of microglia polarization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfc98157fa53c52dd969dc76a098c88 https://pubmed.ncbi.nlm.nih.gov/35437845 Zobrazit plný text záznamu Plný text