Transient state kinetic studies on catalysis and inhibition of staphylococcal beta-lactamase
| Autor: | R Virden |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pharmacology
Circular dichroism Transient state Time Factors Chemistry Staphylococcus Kinetics Substrate (chemistry) Penicillins beta-Lactamases Catalysis Anti-Bacterial Agents Clavulanic Acids Hydrolysis Infectious Diseases Protein structure Oncology Biochemistry Biophysics Humans Pharmacology (medical) beta-Lactamase Inhibitors Beta-Lactamase Inhibitors Clavulanic Acid |
| Zdroj: | Journal of chemotherapy (Florence, Italy). 3(2) |
| ISSN: | 1120-009X |
| Popis: | The interaction of beta-lactamase with a beta-lactam substrate may, in addition to hydrolysis of the beta-lactam by way of an acylenzyme intermediate, lead to transient or permanent inhibition through one or more branches in the catalytic pathway. The balance between these processes depends on the interplay between the chemical reactivities of interacting groups and on effects on protein conformation and stability but the molecular basis is not fully understood. Examples of physical and kinetic probes of some of the mechanisms are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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