Hyaluronic acid grafted nanoparticles of a platinum(ii)–silicon(iv) phthalocyanine conjugate for tumor and mitochondria-targeted photodynamic therapy in red light

Autor:	Montserrat Samsó, Charles E. Lyons, Matthew C. T. Hartman, Koushambi Mitra
Rok vydání:	2018
Předmět:	Silicon Indoles Light medicine.medical_treatment Biomedical Engineering chemistry.chemical_element Antineoplastic Agents Apoptosis Photodynamic therapy 02 engineering and technology Isoindoles Conjugated system 010402 general chemistry 01 natural sciences Article chemistry.chemical_compound Cell Line Tumor Hyaluronic acid medicine Humans General Materials Science Hyaluronic Acid Cytotoxicity Platinum Chemotherapy Photosensitizing Agents General Chemistry General Medicine 021001 nanoscience & nanotechnology Mitochondria 0104 chemical sciences HEK293 Cells Hyaluronan Receptors Photochemotherapy chemistry Phthalocyanine Nanoparticles 0210 nano-technology Nuclear chemistry Conjugate
Zdroj:	Journal of Materials Chemistry B. 6:7373-7377
ISSN:	2050-7518 2050-750X
Popis:	Herein, we report novel hyaluronic acid formulated nanoparticles containing a platinum(II) conjugated silicon(IV) phthalocyanine (SiPc-Pt-HA) for tumor targeted red light photodynamic therapy and chemotherapy. The SiPc-Pt-HA conjugate showed specific uptake, photo-enhanced cytotoxicity (~1500 fold) and mitochondrial accumulation in breast cancer over normal cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfbbfe6a67f462947e38fe0647a11a2 https://doi.org/10.1039/c8tb02533a Zobrazit plný text záznamu