Raloxifene does not influence flow-mediated endothelium-dependent and endothelium-independent vasodilatation of osteopenic postmenopausal women

Autor: Serenella Arangino, Angelo Cagnacci, Annibale Volpe, Anna Lisa Zanni, Antonella Renzi
Rok vydání: 2003
Předmět:
Selective Estrogen Receptor Modulators
medicine.medical_specialty
Endothelium
Lipoproteins
Urology
Hemodynamics
Placebo
LDL
Double-Blind Method
Vascular
Internal medicine
medicine.artery
Humans
Medicine
Raloxifene
Brachial artery
Osteoporosis
Postmenopausal
Blood Circulation
physiology
physiopathology
Female
antagonists /&/ inhibitors/blood
Middle Aged
Osteoporosis
Postmenopausal
drug therapy/physiopathology
therapeutic use
Vasodilation
drug effects/physiology
business.industry
Obstetrics and Gynecology
medicine.disease
Lipoproteins
LDL
Osteopenia
Endocrinology
medicine.anatomical_structure
Blood pressure
Raloxifene Hydrochloride
physiology
Double-Blind Method
Endothelium
physiopathology
Female
Humans
Lipoproteins
antagonists /&/ inhibitors/blood
Middle Aged
Osteoporosis
drug therapy/physiopathology
Raloxifene
therapeutic use
Selective Estrogen Receptor Modulators
therapeutic use
Vasodilation
cardiovascular system
Endothelium
Vascular
business
medicine.drug
Artery
Zdroj: American Journal of Obstetrics and Gynecology. 188:313-317
ISSN: 0002-9378
Popis: Objective: The study was undertaken to evaluate whether raloxifene influences endothelium-dependent and endothelium-independent vasodilatation in women. Study design: In a double-blind, placebo-controlled randomized study, 30 osteopenic but otherwise healthy postmenopausal women received either placebo (n = 15 with one dropout) or raloxifene (60 mg/d, n = 15). Brachial artery flow-mediated endothelium-dependent and endothelium-independent vasodilatation was evaluated by ultrasound before and after 6 months of treatment, along with lipid and glucose metabolism. Endothelium-dependent dilatation was evaluated after a 4-minute block of artery blood flow through a cuff insufflated at suprasystolic blood pressure. Endothelium-independent vasodilatation was evaluated after sublingual nitroglycerin administration (400 μg). Results: Placebo did not modify any vascular or metabolic parameter. Raloxifene significantly decreased low-density lipoprotein levels (4.60 ± 0.18 mmol/L vs 3.94 ± 0.30 mmol/L, P < .015) but did not modify endothelium-dependent (21.6% ± 4.6% vs 20.6% ± 3.8%) or endothelium-independent vasodilatation (26.3% ± 5.1% vs 32.0% ± 5.5%). Conclusion: Prolonged administration of raloxifene does not influence endothelium-dependent and endothelium-independent vasodilatation of osteopenic but otherwise healthy postmenopausal women. (Am J Obstet Gynecol 2003;188:313-7.)
Databáze: OpenAIRE
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