Pathologic Risk Factors and Oncologic Outcomes in Early-stage Cervical Cancer Patients Treated by Radical Hysterectomy and Pelvic Lymphadenectomy at a Thai University Hospital: A 7 year Retrospective Review
| Autor: | Chairat Leelaphatanadit, Suthi Sangkarat, Irene Ruengkhachorn, Malee Warnnissorn, Jutatip Srisombat, Suwanit Therasakvichya |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty Epidemiology medicine.medical_treatment Uterine Cervical Neoplasms Adenocarcinoma Hysterectomy Hospitals University Risk Factors medicine Humans Pelvic Neoplasms Radical Hysterectomy Stage (cooking) Survival rate Cervix Aged Neoplasm Staging Retrospective Studies Cervical cancer business.industry Public Health Environmental and Occupational Health Retrospective cohort study Middle Aged medicine.disease Prognosis Surgery Survival Rate medicine.anatomical_structure Oncology Carcinoma Squamous Cell Lymph Node Excision Female business Follow-Up Studies |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 16(14) |
| ISSN: | 2476-762X |
| Popis: | Background: To evaluate the rate of pathologic high-risk factors, intermediate-risk factors, and treatment outcomes in early-stage cervical cancer patients undergoing radical hysterectomy and pelvic lymphadenectomy (RHPL). Materials and Methods : Medical records of stage IA-IIA1 cervical cancer patients who underwent RHPL during the 2006 to 2012 time period and patient follow-up data until December 2013 were reviewed. Results: Of 331 patients, 52 women (15.7%) had pathologic high-risk factors and 59 women (17.8%) had intermediate-risk factors without high-risk factors. All studied patients had an initial complete response. At median follow-up time of 40.9 months (range 1-103.3 months) and mean follow-up time of 43.3±25.3 months, 37 women had disease recurrence and 4 women had died of disease. The most common site of recurrence was the pelvis (64.8%). Five-year and 10-year disease free survival rates were 96.1% and 91.5%, respectively. Five-year and 10-year overall survival rates were 100% and 99.4%, respectively. Independent factors related to recurrence were pelvic node metastasis (odds ratio [OR], 2.670; 95%CI, 1.001-7.119), and >1/3 cervical stromal invasion (OR, 3.763; 95%CI, 1.483-9.549). Conclusions: The rates of pathologic high-risk and intermediate-risk factors should be considered and disclosed when counseling patients regarding primary treatment by RHPL. Oncologic outcomes of primary surgical treatment for early-stage cervical carcinoma were found to be excellent. Keywords |
| Databáze: | OpenAIRE |
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