5‐Aminolevulinic acid and sodium ferrous citrate ameliorate muscle aging and extend healthspan in Drosophila
| Autor: | Maki Tajima, Shingo Aizawa, Taro Saito, Akiko Asada, Marie Noguchi, Naoko Nozawa, Kanae Ando, Takuya Ishii, Koichi M. Iijima, Kanako Shinno, Masahiro Ishizuka |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
animal structures QH301-705.5 Sodium chemistry.chemical_element Mitochondrion Citric Acid General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Internal medicine medicine Animals Ferrous Compounds Biology (General) Drosophila Research Articles Ferrous citrate reactive oxygen species chemistry.chemical_classification Reactive oxygen species biology Muscles aging Aminolevulinic Acid Muscle functions biology.organism_classification 5‐aminolevulinic acid mitochondria Drosophila melanogaster Endocrinology chemistry muscle architecture Muscle architecture Research Article |
| Zdroj: | FEBS Open Bio FEBS Open Bio, Vol 12, Iss 1, Pp 295-305 (2022) |
| ISSN: | 2211-5463 |
| DOI: | 10.1002/2211-5463.13338 |
| Popis: | Declines in mitochondrial functions are associated with aging. The combination of 5‐aminolevulinic acid (5‐ALA) and sodium ferrous citrate (SFC) improves mitochondrial functions in cultured cells. In this study, we investigated the effects of dietary supplementation with 5‐ALA and SFC (5‐ALA/SFC) on the healthspan and life span of Drosophila melanogaster. Adult Drosophila fruit flies were fed cornmeal food containing various concentrations of 5‐ALA/SFC. Locomotor functions, life span, muscle architecture, and age‐associated changes in mitochondrial function were analyzed. We found that feeding 5‐ALA/SFC mitigated age‐associated declines in locomotor functions and extended organismal life span. Moreover, 5‐ALA/SFC preserved muscle architecture and maintained the mitochondrial membrane potential in aged animals. Since 5‐ALA phosphate/SFC is used as a human dietary supplement, our results suggest that it could be used to slow the age‐related declines in muscle functions, prevent age‐associated clinical conditions such as frailty, and extend healthspan and life span. Age‐related declines in physiological systems cause problematic features such as frailty. In this study, we found that 5‐aminolevulinic acid hydrochloride and sodium ferrous citrate (5‐ALA/SFC) mitigated age‐associated declines in locomotor functions and the muscle architecture, preserved the mitochondrial membrane potential, and extended life span in Drosophila melanogaster. 5‐ALA/SFC might be used to prevent age‐associated clinical conditions. |
| Databáze: | OpenAIRE |
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