Kawasaki Disease: Pathology, Risks, and Management
| Autor: | Mitsuru Seki, Takaomi Minami |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Vascular Stiffness
Endocrinology Diabetes and Metabolism Public Health Environmental and Occupational Health Humans Pharmacology (medical) Hematology General Medicine Coronary Artery Disease Mucocutaneous Lymph Node Syndrome Pulse Wave Analysis Cardiology and Cardiovascular Medicine Atherosclerosis Coronary Vessels |
| Zdroj: | Vascular health and risk management. 18 |
| ISSN: | 1178-2048 |
| Popis: | Kawasaki disease (KD), first reported as an acute febrile mucocutaneous lymph node syndrome, is a self-limiting vasculitis of unknown etiology. The most important aspect of KD is the prevention of coronary artery lesion (CAL) because myocardial ischemia or infarction due to CAL might be lethal. In addition to the CAL, patients with KD develop systemic vasculitis, which indicates the presence of vascular endothelial damage. Studies assessing pulse wave velocity or percentage change in flow-mediated dilatation have shown that aortic stiffness is increased in patients with KD history. In contrast, the cardio-ankle vascular index, a novel parameter not affected by blood pressure, has not demonstrated increased aortic stiffness in patients with KD. Although many studies using various parameters have suggested a risk of atherosclerosis in patients with a history of KD, a few others have reported no significant differences between KD patients and controls. Therefore, it will be necessary to thoroughly understand the characteristics of each parameter, before evaluating the results of those studies, to understand systemic vascular dysfunction in these populations, and to manage their vascular health. Although it is controversial whether the risk of atherosclerosis in patients with KD is higher, those with CAL are thought to be at a high risk of atherosclerosis. Therefore, appropriate treatment to prevent CAL in the acute phase and subsequent regular follow-up is important. Here, we review the pathology, risk, and management of vascular disorders, especially systemic vascular disorders, in patients with KD history. |
| Databáze: | OpenAIRE |
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