Changes in connective tissue in sarcoid granuloma: hyalin, paraamyloid and fibrinoid. Electron microscopic study of 11 cases
| Autor: | Bouteille M, S. R. Kalifat, J. Delarue |
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| Rok vydání: | 1969 |
| Předmět: |
Pathology
medicine.medical_specialty Cytoplasm Hyalin Sarcoidosis Biopsy Connective tissue Pathology and Forensic Medicine law.invention law medicine Humans Lung Mononuclear Phagocyte System medicine.diagnostic_test Staining and Labeling Chemistry Ground substance Anatomy medicine.disease Microscopy Electron medicine.anatomical_structure Giant cell Connective Tissue Reticular connective tissue Ultrastructure Collagen Lymph Nodes Electron microscope |
| Zdroj: | Virchows Archiv. B, Cell pathology. 3(4) |
| Popis: | Studies of changes in the ground substance of sarcoid lesions were made with the electron microscope in tissues from eleven patients with sarcoidosis of the following sites: lymph nodes, skin, and lungs. Comparison was made on the one hand between ultrastructural and histological findings in the sarcoid granuloma, and on the other hand, between our results and the ultrastructural definitions of certain substances, as found in the literature. In addition to uranyl and lead, special stains, namely P.T.A., KMnO4 and Ag, were of great help for identifying various changes in the ground substance. In so-called hyalin substance, two components were detectable: granular substance related to hyalin proper, and microfibrillar substance related to paralamyloid. A third type of change in the ground substance was compared with fibrinoid. Relationship of these substances with intracytoplasmic filaments found in the reticular, epithelioid, and giant cells was discussed. |
| Databáze: | OpenAIRE |
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