Placebo Versus Low-dose Ketamine Infusion in Addition to Remifentanil Target-controlled Infusion for Conscious Sedation During Oocyte Retrieval: A Double-blinded, Randomized Controlled Trial
| Autor: | Luc Barvais, Sarah Saxena, Edgard Engelman, Hélène I Morue, Shalini Raj-Lawrence, Anne Delbaere |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Sedation Conscious Sedation Remifentanil Oocyte Retrieval Placebo law.invention Target controlled infusion 03 medical and health sciences 0302 clinical medicine Patient satisfaction Double-Blind Method Randomized controlled trial 030202 anesthesiology law Humans Medicine Ketamine Prospective Studies Infusions Intravenous Prospective cohort study Analgesics Capnography 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Low dose Placebo Effect Oocyte Analgesics Opioid Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia Drug Therapy Combination Female medicine.symptom Respiratory Insufficiency business medicine.drug |
| Zdroj: | Obstetric Anesthesia Digest. 39:101-102 |
| ISSN: | 0275-665X |
| DOI: | 10.1097/01.aoa.0000557690.37203.85 |
| Popis: | BACKGROUND Currently, there is no gold standard for monitored anaesthesia care during oocyte retrieval. OBJECTIVE In our institution, the standard is a conscious sedation technique using a target-controlled infusion (TCI) of remifentanil, titrated to maintain a visual analogue pain score less than 30 mm. This protocol is well accepted by patients but is associated with frequent episodes of respiratory depression. The main objective of this study was to evaluate whether the addition of a continuous intravenous infusion of ketamine could reduce these episodes. DESIGN Controlled, randomised, prospective, double-blinded study. SETTING The current study was conducted in a tertiary-level hospital in Brussels (Belgium) from December 2013 to June 2014. PATIENTS Of the 132 women undergoing oocyte retrieval included, 121 completed the study. INTERVENTION After randomisation, patients received either a ketamine infusion (40 μg kg min over 5 min followed by 2.5 μg kg min) or a 0.9% saline infusion in addition to the variable remifentanil TCI. MAIN OUTCOME MEASURES The primary outcome was the number of respiratory depression episodes. Effect site target remifentanil concentrations, side effects, pain score, patient satisfaction and incidence of pregnancy were also recorded. RESULTS No significant difference in the incidence of respiratory events was noted (pulse oximetry oxygen saturation |
| Databáze: | OpenAIRE |
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