Nanoparticle Contrast-enhanced MRI for Visualization of Retroplacental Clear Space Disruption in a Mouse Model of Placental Accreta Spectrum (PAS)

Autor: Andrew A. Badachhape, Prajwal Bhandari, Laxman Devkota, Mayank Srivastava, Eric A. Tanifum, Verghese George, Karin A. Fox, Chandrasekhar Yallampalli, Ananth V. Annapragada, Ketan B. Ghaghada
Rok vydání: 2022
Předmět:
Zdroj: Academic Radiology.
ISSN: 1076-6332
DOI: 10.1016/j.acra.2022.08.025
Popis: Prior preclinical studies established the utility of liposomal nanoparticle blood-pool contrast agents in visualizing the retroplacental clear space (RPCS), a marker of normal placentation, while sparing fetuses from exposure because the agent does not cross the placental barrier. In this work, we characterized RPCS disruption in a mouse model of placenta accreta spectrum (PAS) using these agents.Contrast-enhanced MRI (CE-MRI) and computed tomography (CE-CT) using liposomal nanoparticles bearing gadolinium (liposomal-Gd) and iodine were performed in pregnant Gab3Pregnant Gab3Imaging of the Gab3
Databáze: OpenAIRE