Indications, protocols, and outcomes of drug desensitizations for chemotherapy and monoclonal antibodies in adults and children
| Autor: | David I. Hong, Anahita F. Dioun |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Drug
Adult medicine.medical_specialty Allergy medicine.drug_class medicine.medical_treatment media_common.quotation_subject Antineoplastic Agents Monoclonal antibody Severity of Illness Index Drug Administration Schedule Drug Hypersensitivity Predictive Value of Tests Risk Factors medicine Immunology and Allergy Humans Intensive care medicine Child Desensitization (medicine) media_common Skin Tests Chemotherapy business.industry Drug Administration Routes Patient Selection Antibodies Monoclonal Patient survival medicine.disease Hypersensitivity reaction Treatment Outcome Desensitization Immunologic Immunology Monoclonal business |
| Zdroj: | The journal of allergy and clinical immunology. In practice. 2(1) |
| ISSN: | 2213-2198 |
| Popis: | Advances in the understanding of various malignancies and chronic inflammatory diseases has led to the development of better treatment options for prolonging patient survival and minimizing morbidity. The recognition of "first-line" chemotherapy and monoclonal agents for these conditions has given more urgency to the need to re-administer these drugs in cases of drug hypersensitivity reactions. Therefore, in these cases, not only is desensitization considered when there is no alternative therapy available but also when alternative treatments are considered therapeutically inferior and/or more toxic. In this article, we describe the steps involved in the evaluation of these patients, factors to consider before making a decision to desensitize, the implementation of desensitization protocols, and the outcomes of such procedures. |
| Databáze: | OpenAIRE |
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