Cancer-associated gene analysis of cervical cytology samples and liquid-based cytology significantly improve endometrial cancer diagnosis sensitivity

Autor:	Ryo Nimura, Eiji Kondo, Kenta Yoshida, Michiko Kubo‑Kaneda, Masafumi Nii, Makoto Ikeijiri, Maki Nakamura, Hiroshi Imai, Yoshinaga Okugawa, Kaname Nakatani, Tomoaki Ikeda
Rok vydání:	2022
Předmět:	Cancer Research Oncology
Zdroj:	Oncology letters. 24(4)
ISSN:	1792-1082
Popis:	To the best of our knowledge, there are no useful screening methods for early detection of endometrial cancer in asymptomatic individuals. The present study evaluated the usefulness of genetic analysis of liquid-based cytology (LBC) specimens by assessing whether pathological genetic mutations detected in cancer tissue sections were detected in LBC specimens from the cervix and uterus. The primary endpoint was genetic analysis of cervical cytology specimens and LBC for the detection of endometrial cancer. Endometrial thickening (11 mm) assessed using transvaginal ultrasonography was present in 60% of cases and adenocarcinoma assessed using cervical cytology was present in 50% of cases. In 70% of cases, pathogenic mutations detected in cancer tissue sections were also detected in cervical and/or endometrial LBC specimens. The pathogenic variants identified were
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df53cb50b1162b4d9a4f091f4efe0ff https://pubmed.ncbi.nlm.nih.gov/36238840 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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