Finding the combination of multiple biomarkers to diagnose oral squamous cell carcinoma – A data mining approach

Autor: Nattane Luíza da Costa, Mariana de Sá Alves, Nayara de Sá Rodrigues, Celso Muller Bandeira, Mônica Ghislaine Oliveira Alves, Maria Anita Mendes, Levy Anderson Cesar Alves, Janete Dias Almeida, Rommel Barbosa
Přispěvatelé: Science and Technology, Universidade Estadual Paulista (UNESP), Universidade Mogi das Cruzes, Anhembi Morumbi University, Universidade de São Paulo (USP), Universidade Paulista, Universidade Municipal de São Caetano do Sul, Universidade Federal de Goiás (UFG)
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Popis: Made available in DSpace on 2022-05-01T13:41:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-04-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Data mining has proven to be a reliable method to analyze and discover useful knowledge about various diseases, including cancer research. In particular, data mining and machine learning algorithms to study oral squamous cell carcinoma (OSCC), the most common form of oral cancer, is a new area of research. This malignant neoplasm can be studied using saliva samples. Saliva is an important biofluid that must be used to verify potential biomarkers associated with oral cancer. In this study, first, we provide an overview of OSSC diagnoses based on machine learning and salivary metabolites. To our knowledge, this is the first study to apply advanced data mining techniques to diagnose OSCC. Then, we give new results of classification and feature selection algorithms used to identify potential salivary biomarkers of OSCC. To accomplish this task, we used the filter feature selection random forest importance algorithm and a wrapper methodology to evaluate the importance of metabolites obtained from gas chromatography mass-spectrometry (GC-MS) in the context of differentiation of OSCC and the control group. Salivary samples (n = 68) were collected for the control group, and the OSCC group were from patients matched for gender, age, and smoking habit. The classification process occurred based on Random Forest (RF) classification algorithm along with 10-cross validation. The results showed that glucuronic acid, maleic acid, and batyl alcohol can classify the samples with an area under the curve (AUC) of 0.91 versus an AUC of 0.76 using all 51 metabolites analyzed. The methodology used in this study can assist healthcare professionals and be adopted to discover diagnostic biomarkers for other diseases. Informatics Nucleo Goiano Federal Institute of Education Science and Technology, Campus Urutaí Department of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp) Technology Reaearch Center (NPT) Universidade Mogi das Cruzes School of Medicine Anhembi Morumbi University Dempster MS Lab Universidade de São Paulo School of Dentistry Universidade Paulista School of Dentistry Universidade Municipal de São Caetano do Sul Instituto de Informática Universidade Federal de Goiás Department of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp) FAPESP: 2016/08633-0
Databáze: OpenAIRE
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