Intracerebral xenografts of mouse bone marrow cells in adult rats facilitate restoration of cerebral blood flow and blood-brain barrier

Autor: Martin Hadman, Ora Dillon-Carter, David C. Hess, Jeffrey G Lind, James E. Carroll, Charles Y. Cheng, Guolong Yu, Cesario V. Borlongan
Rok vydání: 2004
Předmět:
Male
Pathology
medicine.medical_specialty
Time Factors
Green Fluorescent Proteins
Transplantation
Heterologous
Vascular permeability
Bone Marrow Cells
Enzyme-Linked Immunosorbent Assay
Biology
Blood–brain barrier
Capillary Permeability
Rats
Sprague-Dawley
Stereotaxic Techniques
chemistry.chemical_compound
Mice
medicine
Laser-Doppler Flowmetry
Animals
Nerve Growth Factors
Molecular Biology
Evans Blue
Bone Marrow Transplantation
General Neuroscience
Recovery of Function
Rats
Transplantation
Mice
Inbred C57BL
Luminescent Proteins
medicine.anatomical_structure
nervous system
Cerebral blood flow
chemistry
Blood-Brain Barrier
Regional Blood Flow
Brain Injuries
Cerebrovascular Circulation
Stereotaxic technique
Immunology
cardiovascular system
Neurology (clinical)
Bone marrow
Perfusion
Developmental Biology
Zdroj: Brain research. 1009(1-2)
ISSN: 0006-8993
Popis: We examined in the present study alterations in cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability following intrastriatal transplantation of mouse bone marrow stromal cells (BMSCs) or saline infusion in adult Sprague-Dawley rats. Laser Doppler revealed that transplanted animals exhibited near normal cerebral blood flow (CBF, 150 perfusion units) at a much earlier period post-transplantation (day 4) compared to animals that received saline infusion (day 12) (p's
Databáze: OpenAIRE
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