High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis
| Autor: | Carmelo Luigiano, Aldo Spadaro, Vincenza Tortorella, Freni Ma, Paola Composto, Antonino Ajello, Giuseppe De Caro, Carmela Morace, Oscar Ferraù, Angela Alibrandi, Caterina Bonfiglio, Agostino Fortiguerra |
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| Rok vydání: | 2008 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis Carcinoma Hepatocellular Gastroenterology Group A Group B Fibrin Fibrinogen Degradation Products Liver disease Basal (phylogenetics) Internal medicine Ascites Carcinoma Medicine Humans Paracentesis Diuretics Aged Aged 80 and over business.industry Liver Neoplasms General Medicine Diet Sodium-Restricted Middle Aged medicine.disease Hepatocellular carcinoma Disease Progression Female medicine.symptom business Rapid Communication |
| Zdroj: | World journal of gastroenterology. 14(10) |
| ISSN: | 1007-9327 |
| Popis: | AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity. |
| Databáze: | OpenAIRE |
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