Long term dietary supplementation with zeaxanthin reduces photoreceptor death in light-damaged Japanese quail
| Autor: | Neal E. Craft, François C. Delori, C. Kathleen Dorey, Kevin M. Garnett, Yoko Toyoda, Lauren R. Thomson, Z.-Y. Wong, Cathleen R. Nichols, Kimberly M. Cheng |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Lutein Time Factors Light Tocopherols Apoptosis Coturnix Biology Xanthophylls Photoreceptor cell Cellular and Molecular Neuroscience chemistry.chemical_compound Retinal Diseases Zeaxanthins Internal medicine Botany medicine Animals Macula Lutea Carotenoid chemistry.chemical_classification Retina Age Factors food and beverages Retinal beta Carotene Carotenoids eye diseases Sensory Systems Age-related maculopathy Zeaxanthin Ophthalmology medicine.anatomical_structure Endocrinology chemistry Xanthophyll Dietary Supplements Female sense organs Photoreceptor Cells Vertebrate |
| Zdroj: | Experimental eye research. 75(5) |
| ISSN: | 0014-4835 |
| Popis: | The purpose of these studies was to evaluate the effects of light damage on Japanese quail whose retinal carotenoids had been experimentally manipulated through altered diets. The birds were raised 6 months on a commercial turkey diet (T), on a custom carotenoid-deficient diet (C-) containing 90% less carotenoid than the T diet, or on Z+ diet [the C- diet supplemented with natural zeaxanthin (35mgkg(-1) food)]. Equal numbers of males and females on each diet were exposed to nine intervals (1hr on, 2hr off) of 3200lux cool white light, then placed in the dark for 14hr before tissue collection. One retina was immediately frozen for HPLC analysis; the other eye was immediately fixed and processed for microscopy. There were no significant differences in the retinal carotenoid concentrations in hatch-mates that were and were not exposed to light. Supplementation resulted in three- to four-fold increases in retinal zeaxanthin and no change in retinal lutein or alpha-tocopherol, but the C- diet did not reduce the retinal carotenoid concentration in C- birds below that in T birds. The light-exposed retinas had significant numbers of apoptotic photoreceptors and photoreceptor ghosts. The number of ghosts was negatively correlated with the number of dying photoreceptors (P |
| Databáze: | OpenAIRE |
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