Immunogenicity of a Reduced Schedule of Pneumococcal Conjugate Vaccine in Healthy Infants and Correlates of Protection for Serotype 6B in the United Kingdom
| Autor: | Lindsey Ashton, Nick Andrews, Elizabeth Miller, David Goldblatt, Jo Southern, Polly Burbidge, Pauline Waight, Sarah Woodgate |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Microbiology (medical) Heptavalent Pneumococcal Conjugate Vaccine Immunization Secondary Meningococcal Vaccines Context (language use) complex mixtures Measles Rubella Pneumococcal conjugate vaccine Pneumococcal Vaccines Humans Medicine Bacterial Capsules Immunization Schedule Haemophilus Vaccines business.industry Immunogenicity Polysaccharides Bacterial Vaccination Infant medicine.disease Antibodies Bacterial Virology United Kingdom Infectious Diseases Immunization Pediatrics Perinatology and Child Health Immunology Female business Measles-Mumps-Rubella Vaccine medicine.drug |
| Zdroj: | Pediatric Infectious Disease Journal. 29:401-405 |
| ISSN: | 0891-3668 |
| Popis: | Background: Pneumococcal conjugate vaccine (PCV) was introduced in the United Kingdom immunization schedule in September 2006. This study was conducted to establish the immunogenicity of licensed PCV (Prevenar) at a reduced, 2 priming dose schedule (2 + 1) and to evaluate functional responses in the context of vaccine effectiveness.Methods: Infants were randomized to receive PCV at 2 and 3 months or 2 and 4 months of age. Boosters were administered at the same time as Haemophilus influenzae type B/meningococcal C conjugate and Measles, Mumps and Rubella or with Measles, Mumps and Rubella alone (www.ClinicalTrials.gov NCT00197808).Results: PCV at 2/3 months of age was poorly immunogenic and recruitment to this arm was terminated. PCV at 2/4 months of age resulted in lower than expected responses to serotypes 6B and 23F. Functional analysis of serotype 6B by OPA revealed that an enzyme-linked immunosorbent assay cutoff of 0.2 mu g/mL was a better predictor of OPA positivity than a cut off of 0.35 mu g/mL. PCV booster responses were excellent and no interference from concomitant vaccines was noted.Conclusions: An interval of at least 8 weeks is required when starting PCV vaccination at 2 months of age although not all serotypes are equally immunogenic. Correlates of protection derived from enzyme-linked immunosorbent assay values may not be equally appropriate for all serotypes as illustrated by results for 6B in this study. |
| Databáze: | OpenAIRE |
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