Morphological changes in the human endocrine pancreas induced by chronic excess of endogenous glucagon
| Autor: | Tatiana Bani Sacchi, G Biliotti, Daniele Bani |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Pancreatic disease Adolescent endocrine system diseases Glucagonoma Nesidioblastosis Biology Pancreatic Polypeptide Glucagon Immunoenzyme Techniques Islets of Langerhans Internal medicine medicine Humans Insulin Pancreatic polypeptide Pancreas Pancreatic islets Middle Aged medicine.disease Pancreatic Neoplasms Somatostatin Endocrinology medicine.anatomical_structure Female |
| Zdroj: | Virchows Archiv B Cell Pathology Including Molecular Pathology. 60:199-206 |
| ISSN: | 0042-6431 |
| DOI: | 10.1007/bf02899547 |
| Popis: | The non-tumoral endocrine pancreas from a patient with elevated plasma levels of glucagon due to a malignant glucagonoma was studied immunocytochemically, ultrastructurally and morphometrically. Compared with normal pancreatic islets from control subjects, those of the pancreas from the patient with a glucagonoma showed an almost complete disappearance of A cells, a decrease in immunoreactive insulin in B cells associated with cytological features indicating enhanced synthesis and secretion of this hormone, and an increase in immunoreactive somatostatin and pancreatic polypeptide (PP) accompanied by unusually high numbers of D and PP cells. In addition, numerous B cells were found outside the islets, either forming micro-islets or scattered in the exocrine tissue (nesidioblastosis). The possible mechanisms involved in determining the changes in the secretory activity of B cells and the alterations in the cell composition of the islets are discussed. |
| Databáze: | OpenAIRE |
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