Lipoprotein(a), Immunity, and Inflammation in Polyvascular Atherosclerotic Disease
| Autor: | Marat V. Ezhov, N.A. Tmoyan, Olga I. Afanasieva, Sergei N. Pokrovsky, E.A. Klesareva, Tatiana V Balakhonova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system atherosclerosis of lower limb arteries autoantibodies carotid artery disease Type 2 diabetes Gastroenterology Article C-reactive protein Coronary artery disease lipoprotein(a) Internal medicine Carotid artery disease Medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics hyperlipoproteinemia(a) apolipoprotein(a) circulating immune complexes atherosclerosis coronary artery disease medicine.diagnostic_test biology business.industry Autoantibody Lipoprotein(a) medicine.disease lcsh:RC666-701 biology.protein business Lipid profile Lipoprotein |
| Zdroj: | Journal of Cardiovascular Development and Disease, Vol 8, Iss 11, p 11 (2021) Journal of Cardiovascular Development and Disease; Volume 8; Issue 2; Pages: 11 Journal of Cardiovascular Development and Disease |
| ISSN: | 2308-3425 |
| Popis: | Background and aims: lipoprotein(a) (Lp(a)) is a genetically determined risk factor for coronary artery disease and its complications, although data on the association with other vascular beds and the severity of atherosclerosis is limited. The aim of this study was to evaluate the association of atherosclerosis of various vascular beds with Lp(a), as well as its autoantibodies and generalized inflammatory markers. Material and methods: this study included 1288 adult patients with clinical and imaging examination of three vascular beds (coronary, carotid, and lower limb arteries). Patients were categorized according to the number of affected vascular beds (with at least one atherosclerotic stenosis ≥50%): 0 (n = 339), 1 (n = 470), 2 (n = 315), 3 (n = 164). We assessed blood cell count, lipid profile, C-reactive protein, circulating immune complexes, Lp(a), and its autoantibodies. Results: the number of affected vascular beds was associated with an increasing level of Lp(a) and a lower level of IgM autoantibodies to Lp(a). Hyperlipoproteinemia(a) (Lp(a) ≥ 30 mg/dL) was detected more frequently in patients with atherosclerosis. In logistic regression analysis adjusted for age, sex, hypertension, type 2 diabetes, and smoking, an elevated Lp(a) level was independently associated with stenotic atherosclerosis and lesion severity. There was a positive association of the number of affected vascular beds with C-reactive protein (r = 0.21, p < 0.01) and a negative association with circulating immune complexes (r = −0.29, p < 0.01). The neutrophil-to-lymphocyte ratio was significantly higher and the lymphocyte-to-monocyte ratio was significantly lower in patients with atherosclerosis compared to the controls (p < 0.01). Conclusion: Lp(a), C-reactive protein, circulating immune complexes, and neutrophil-to-lymphocyte ratio are associated with the stenotic atherosclerosis of different vascular beds. Lp(a) levels increase and IgM autoantibodies to Lp(a) decrease with the number of affected vascular beds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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