The Use of Coupled Plasma Filtration Adsorption in Traumatic Rhabdomyolysis
| Autor: | Annamaria Scozzafava, Silvia Renda, Mario Pezzi, Fabrizio Iannelli, Simona Paola Tiburzi, Patrizia Casella, Mario Verre, Anna Maria Giglio |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Potassium medicine.medical_treatment Sarcoplasm 030232 urology & nephrology Urology chemistry.chemical_element Case Report Glomerulus (kidney) Critical Care and Intensive Care Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hemofiltration Medicine 030212 general & internal medicine Creatinine biology business.industry lcsh:Medical emergencies. Critical care. Intensive care. First aid lcsh:RC86-88.9 medicine.disease Surgery medicine.anatomical_structure Myoglobin chemistry biology.protein Creatine kinase business Rhabdomyolysis |
| Zdroj: | Case Reports in Critical Care, Vol 2017 (2017) Case Reports in Critical Care |
| ISSN: | 2090-6439 2090-6420 |
| Popis: | Severe musculoskeletal injuries induce the release of sarcoplasmic elements such as muscle enzymes, potassium, and myoglobin in the systemic circulation. The circulating myoglobin damages the glomerulus and renal tubules. Conventional haemodialysis is not able to remove myoglobin, due to its high molecular weight (17,8 kilodaltons [kDa]). We treated four traumatic rhabdomyolysis patients with Coupled Plasma Filtration Adsorption (CPFA) in order to remove myoglobin followed by 14 hours of Continuous Veno-Venous Hemofiltration (CVVH). During the treatment, all patients showed clinical improvement with a decrease in muscular (creatine kinase [CK] and myoglobin) and renal (creatinine and potassium) damage indices. One patient, in spite of full renal recovery, died of cerebral haemorrhage on the 26th day of hospital stay. |
| Databáze: | OpenAIRE |
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