Actin retrograde flow controls natural killer cell response by regulating the conformation state of SHP ‐1
| Autor: | Sophia Fried, Noah Joseph, Elad Noy, Omri Matalon, Mira Barda-Saad, Aviad Ben-Shmuel, Guy Biber, Batel Sabag, Jessica Kivelevitz |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Protein Conformation macromolecular substances Biology Mechanotransduction Cellular General Biochemistry Genetics and Molecular Biology Natural killer cell 03 medical and health sciences 0302 clinical medicine Immune system medicine Humans Mechanotransduction Cytoskeleton Cytotoxicity Molecular Biology Cells Cultured Actin General Immunology and Microbiology Protein Tyrosine Phosphatase Non-Receptor Type 6 General Neuroscience Actomyosin Articles Actin cytoskeleton Actins Cell biology Killer Cells Natural Actin Cytoskeleton 030104 developmental biology medicine.anatomical_structure Signal transduction 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | The EMBO Journal. 37 |
| ISSN: | 1460-2075 0261-4189 |
| DOI: | 10.15252/embj.201696264 |
| Popis: | Natural killer (NK) cells are a powerful weapon against viral infections and tumor growth. Although the actin–myosin (actomyosin) cytoskeleton is crucial for a variety of cellular processes, the role of mechanotransduction, the conversion of actomyosin mechanical forces into signaling cascades, was never explored in NK cells. Here, we demonstrate that actomyosin retrograde flow (ARF) controls the immune response of primary human NK cells through a novel interaction between β‐actin and the SH2‐domain‐containing protein tyrosine phosphatase‐1 (SHP‐1), converting its conformation state, and thereby regulating NK cell cytotoxicity. Our results identify ARF as a master regulator of the NK cell immune response. Since actin dynamics occur in multiple cellular processes, this mechanism might also regulate the activity of SHP‐1 in additional cellular systems. |
| Databáze: | OpenAIRE |
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