Corticotropin-Releasing Factor (CRF) Neurocircuitry and Neuropharmacology in Alcohol Drinking
| Autor: | Allyson L. Schreiber, Nicholas W. Gilpin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty Alcohol Drinking Corticotropin-Releasing Hormone Binge drinking Alcohol Alcohol use disorder Receptors Corticotropin-Releasing Hormone Article 03 medical and health sciences chemistry.chemical_compound Neuropharmacology 0302 clinical medicine Internal medicine medicine Animals Humans Urocortins Urocortin business.industry Alcohol dependence Brain medicine.disease 030104 developmental biology Endocrinology chemistry Brain stimulation reward Carrier Proteins business hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
| Zdroj: | The Neuropharmacology of Alcohol ISBN: 9783319965222 |
| DOI: | 10.1007/164_2017_86 |
| Popis: | Alcohol use is pervasive in the United States. In the transition from non-hazardous drinking to hazardous drinking and alcohol use disorder, neuroadaptations occur within brain reward and brain stress systems. One brain signaling system that has received much attention in animal models of excessive alcohol drinking and alcohol dependence is corticotropin-releasing factor (CRF). The CRF system is composed of CRF, the urocortins, CRF-binding protein, and two receptors – CRF-type 1 and CRF-type 2. This review summarizes how acute, binge, and chronic alcohol dysregulate CRF signaling in hypothalamic and extra-hypothalamic brain regions, and how this dysregulation may contribute to changes in alcohol reinforcement, excessive alcohol consumption, symptoms of negative affect during withdrawal, and alcohol relapse. In addition, it summarizes clinical work examining CRF-type 1 receptor antagonists in humans and discusses why the brain CRF system is still relevant in alcohol research. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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