Metabolic imprinting, programming and epigenetics

Autor: Lucien F. Harthoorn, Marjan Gros, Michael E. Symonds, Alain Grynberg, Katherine Macé, Bryan Hanley, Fiona Samuels, Sandra Hummel, Harald Renz, Claudine Junien, Berthold Koletzko, Jean Dijane, Mary Fewtrell, Eline M. van der Beek, Sarah J Lewis
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Metabolic imprinting
POLYUNSATURATED FATTY-ACID
MATERNAL NUTRIENT RESTRICTION
RANDOMIZED CONTROLLED-TRIAL
BETA-CELL AUTOIMMUNITY
FORMULA-FED INFANTS
NEONATAL BONE MASS
DEPENDENT DIABETES-MELLITUS
BIRTH-WEIGHT
PRETERM INFANTS
BLOOD-PRESSURE
Medicine (miscellaneous)
Prenatal Nutritional Physiological Phenomena
Biology
Biomarkers/analysis
Developmental psychology
Epigenesis
Genetic
Metabolic Diseases
Genetic
Models
Pregnancy
Health care
Animals
Humans
Genetic Predisposition to Disease
Epigenetics
Obesity
Cardiovascular Diseases/etiology
Infant Nutritional Physiological Phenomena
Genetics
Developmental stage
Nutrition and Dietetics
business.industry
Dietary exposure
Animal
Infant
Obesity/etiology
Metabolic Diseases/etiology
Diet
Cardiovascular Diseases
Prenatal Exposure Delayed Effects
Models
Animal
Female
business
Reprogramming
Biomarkers
Epigenesis
Zdroj: BRIT J NUTR, 104 (S1) S1-S25. (2010)
ISSN: 0007-1145
DOI: 10.1017/s0007114510003338
Popis: Metabolic programming and metabolic imprinting describe early life events, which impact upon on later physiological outcomes. Despite the increasing numbers of papers and studies, the distinction between metabolic programming and metabolic imprinting remains confusing. The former can be defined as a dynamic process whose effects are dependent upon a critical window(s) while the latter can be more strictly associated with imprinting at the genomic level. The clinical end points associated with these phenomena can sometimes be mechanistically explicable in terms of gene expression mediated by epigenetics. The predictivity of outcomes depends on determining if there is causality or association in the context of both early dietary exposure and future health parameters. The use of biomarkers is a key aspect of determining the predictability of later outcome, and the strengths of particular types of biomarkers need to be determined. It has become clear that several important health endpoints are impacted upon by metabolic programming/imprinting. These include the link between perinatal nutrition, nutritional epigenetics and programming at an early developmental stage and its link to a range of future health risks such as CVD and diabetes. In some cases, the evidence base remains patchy and associative, while in others, a more direct causality between early nutrition and later health is clear. In addition, it is also essential to acknowledge the communication to consumers, industry, health care providers, policy-making bodies as well as to the scientific community. In this way, both programming and, eventually, reprogramming can become effective tools to improve health through dietary intervention at specific developmental points.
Databáze: OpenAIRE
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