Myeloid-derived suppressor cell-like fibrocytes are increased and associated with preserved lung function in chronic obstructive pulmonary disease
| Autor: | Adam K. A. Wright, Sunil Gupta, Bethan Barker, Ruth Saunders, K. Edwards, Christopher E. Brightling, Tracy Thornton, M. Shelley, Ruth Hartley, Katy M. Roach, Vijay Mistry, Rachid Berair, Chris Newby |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty education Immunology Pulmonary disease Cell Count Air trapping Severity of Illness Index Collagen type 1 Immunophenotyping Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Internal medicine Fibrocyte medicine Humans Immunology and Allergy Lung function Aged business.industry Myeloid-Derived Suppressor Cells Cell Differentiation Fibroblasts Middle Aged respiratory system Patient specific Flow Cytometry Respiratory Function Tests respiratory tract diseases Phenotype 030104 developmental biology Airway disease 030228 respiratory system Case-Control Studies Myeloid-derived Suppressor Cell Female medicine.symptom Tomography X-Ray Computed business Biomarkers |
| Zdroj: | Allergy. 72:645-655 |
| ISSN: | 0105-4538 |
| DOI: | 10.1111/all.13061 |
| Popis: | The role of fibrocytes in chronic obstructive pulmonary disease (COPD) is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease.Utilizing flow cytometry to identify circulating, collagen type 1Blood and tissue fibrocytes were not increased compared to control subjects nor were blood fibrocytes associated with lung function or qCT, but were increased in eosinophilic COPD. Myeloid-derived suppressor cell-like fibrocytes were increased in COPD compared to controls [2.3 (1.1-4.9), P = 0.038]. Our path analysis model showed that collagen type 1 intensity for MDSC-like fibrocytes was positively associated with lung function through associations with air trapping, predominately in the upper lobes.We have demonstrated that two circulating populations of fibrocyte exist in COPD, with distinct clinical associations, but are not prevalent in proximal or small airway tissue. Blood MDSC-like fibrocytes, however, are increased and associated with preserved lung function through a small airway-dependent mechanism in COPD. |
| Databáze: | OpenAIRE |
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