Bioassay for A-56268 (TE-031) and identification of its major metabolite, 14-hydroxy-6-O-methyl erythromycin
| Autor: | R. A. Rode, N. Ramer, P. B. Fernandes, L. Freiberg |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Microbiology (medical)
Chromatography Plasma samples Metabolite Erythromycin General Medicine Micrococcus chemistry.chemical_compound Infectious Diseases chemistry Clarithromycin medicine Humans Bioassay Biological Assay Acetonitrile Chromatography High Pressure Liquid Active metabolite medicine.drug |
| Zdroj: | European Journal of Clinical Microbiology & Infectious Diseases. 7:73-76 |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/bf01962181 |
| Popis: | A-56268 is a new macrolide which is generally two-fold more potent than erythromycin. A new bioassay is described in which plasma samples are extracted with acetonitrile prior to bioassay. The concentration range for the assay is between 0.05-4.0 micrograms/ml, and the concentrations measured are within 6% of those measured by high-power liquid chromatography. An active metabolite which is as active as erythromycin was identified in the plasma. The plasma half-life and area under the plasma curve values of A-56268, as determined by bioassay, were significantly greater than those of erythromycin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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