Spirulina liquid extract prevents metabolic disturbances and improves liver sphingolipids profile in hamster fed a high-fat diet
| Autor: | Marine Coué, Audrey Aguesse, Isabelle Grit, Thomas Souque, Fatima Kasbi-Chadli, Khadija Ouguerram, Véronique Ferchaud-Roucher |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Very low-density lipoprotein medicine.medical_specialty Medicine (miscellaneous) Hamster 030209 endocrinology & metabolism Diet High-Fat medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cricetinae Internal medicine Hyperlipidemia Spirulina Animals Medicine Sphingolipids 030109 nutrition & dietetics Nutrition and Dietetics biology Plant Extracts business.industry Cholesterol medicine.disease Endocrinology Postprandial Liver chemistry HMG-CoA reductase biology.protein lipids (amino acids peptides and proteins) Metabolic syndrome business Oxidative stress |
| Zdroj: | European Journal of Nutrition. 60:4483-4494 |
| ISSN: | 1436-6215 1436-6207 |
| DOI: | 10.1007/s00394-021-02589-x |
| Popis: | Metabolic syndrome is characterized by hyperglycemia, hyperlipemia and exacerbated oxidative stress. The aim of the study was to determine whether Spirulysat®, a Spirulina liquid extract (SLE) enriched in phycocyanin, would prevent metabolic abnormalities induced by high-fat diet. The effect of acute SLE supplementation on postprandial lipemia and on triton-induced hyperlipidemia was studied in hamster fed control diet (C). The effect of chronic SLE supplementation on lipid content in plasma, liver and aorta, and on glycemia and oxidative stress was studied in hamster fed control (C) or high-fat diet (HF) for two weeks and then treated with SLE for two weeks (CSp and HFSp) or not (C and HF). The acute SLE supplementation lowered plasma cholesterol and non-esterified fatty acid concentrations after olive oil gavage (P |
| Databáze: | OpenAIRE |
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