The Impact of Iron Overload in Acute Leukemia: Chronic Inflammation, But Not the Presence of Nontransferrin Bound Iron is a Determinant of Oxidative Stress
| Autor: | Ülkü M. Yildirim, Tuncay Hazirolan, Yunus Kasim Terzi, Havva Fatma Balci, Mustafa Serteser, Sibel A. Tekgündüz, Murat Kolay, Lale Olcay |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Iron Overload Acute myeloblastic leukemia medicine.medical_treatment Iron Inflammation medicine.disease_cause 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Receptors Transferrin medicine Humans Receptor Child Acute leukemia Chemotherapy business.industry Case-control study Transferrin Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Pathophysiology Oxidative Stress 030104 developmental biology Oncology 030220 oncology & carcinogenesis Case-Control Studies Pediatrics Perinatology and Child Health Immunology Ferritins Female medicine.symptom business Oxidative stress |
| Zdroj: | Journal of pediatric hematology/oncology. 39(6) |
| ISSN: | 1536-3678 |
| Popis: | In the literature, studies on the oxidant effects of nontransferrin bound iron [NTBI (eLPI assay)] during chemotherapy of acute lymphoblastic leukemia and acute myeloblastic leukemia are lacking. We established NTBI and oxidative stress determinants (OSD), iron parameters, high-sensitive C-reactive protein (hs-CRP) levels, liver tests, cumulative chemotherapeutic doses, and transfused blood in 36 children with acute leukemia throughout chemotherapy. These parameters were determined at the beginning and end of chemotherapy blocks (11 time points) and in 20 healthy children using enzyme-linked immunosorbent assay, and colorimetric and fluorometric enzymatic methods. In acute lymphoblastic leukemia, NTBI, OSD, and hs-CRP were higher than controls at 4/11, 7/11, and 9/11 time points (P0.05). OSD did not correlate with NTBI, but correlated with hs-CRP. In conclusion, NTBI is a poor predictor of OSD in acute leukemia possibly because of the heterogeneity of NTBI and chronic inflammation. Further studies are needed to delineate the pathophysiology of these diseases. |
| Databáze: | OpenAIRE |
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