Altered immunoreactive levels of G proteins in peripheral mononuclear cells of patients with anorexia nervosa and bulimia nervosa
| Autor: | Palmiero Monteleone, Mario Maj, A. Di Lieto, Vassilis Martiadis, Marilena Pannuto |
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| Přispěvatelé: | Monteleone, P, DI LIETO, A, Martiadis, V, Pannuto, M, Maj, Mario |
| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty Anorexia Nervosa Adolescent G protein Blotting Western GTP-Binding Protein alpha Subunits Gi-Go Severity of Illness Index behavioral disciplines and activities Peripheral blood mononuclear cell Cellular and Molecular Neuroscience Internal medicine mental disorders GTP-Binding Protein alpha Subunits Gs medicine Humans Statistical analysis Bulimia Molecular Biology Bulimia nervosa GTP-Binding Protein beta Subunits digestive oral and skin physiology medicine.disease Pathophysiology Peripheral Psychiatry and Mental health Endocrinology Anorexia nervosa (differential diagnoses) Leukocytes Mononuclear GTP-Binding Protein alpha Subunits Gq-G11 Female Signal transduction Psychology hormones hormone substitutes and hormone antagonists Signal Transduction |
| Zdroj: | Molecular Psychiatry. 8:680-684 |
| ISSN: | 1476-5578 1359-4184 |
| DOI: | 10.1038/sj.mp.4001304 |
| Popis: | Alterations of cellular G proteins have been implicated in the pathophysiology of some psychiatric disorders. So far, no study assessed G protein function in anorexia nervosa (AN) and bulimia nervosa (BN). Therefore, we measured immunoreactive levels of G(alpha s), G(alpha i), G(alpha q/11) and G(beta) protein subunits in mononuclear leukocytes of 71 drug-free women, including 25 subjects with AN, 26 individuals with BN and 20 healthy controls. As compared to healthy women, anorexic patients exhibited significantly increased levels of G(alpha i) and G(beta) proteins, while bulimic patients had significantly increased levels of G(alpha s), G(alpha i) and G(beta) proteins. Immunoreactive levels of peripheral G protein subunits were not significantly correlated with demographic or nutritional parameters. These findings, although obtained in peripheral blood cells, may suggest a derangement of G protein-mediated signal transduction in the pathophysiology of eating disorders. |
| Databáze: | OpenAIRE |
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