The effects of ingestion of hydrogen-dissolved alkaline electrolyzed water on stool consistency and gut microbiota: a double-blind randomized trial

Autor:	Yuji Naito, Yasuki Higashimura, Yoshinori Tanaka, Masataka Kiuchi, Katsuhiro Koyama
Rok vydání:	2021
Předmět:	medicine.medical_specialty Neuroscience (miscellaneous) Gut flora bifidobacterium digestive system Gastroenterology law.invention Double blind Eating Feces fluids and secretions Bristol stool scale Randomized controlled trial law Internal medicine medicine Humans Ingestion 16S rRNA antioxidative properties Bifidobacterium double-blind randomized trial Stool consistency alkaline electrolyzed water gut microbiota biology business.industry Water biology.organism_classification stool consistency Gastrointestinal Microbiome Anesthesiology and Pain Medicine gastrointestinal symptoms hydrogen Defecation next-generation sequencing business Research Article
Zdroj:	Medical Gas Research
ISSN:	2045-9912
DOI:	10.4103/2045-9912.318858
Popis:	A relationship between Bifidobacterium and defecation has previously been reported. Our hypothesis on the effectiveness of alkaline electrolyzed water (AEW) proposes that ingestion of AEW, considered possessing antioxidative properties, increases the number of Bifidobacteria and improves stool hardness and gastrointestinal symptoms. A double-blind, randomized study was conducted to evaluate the connection between stool consistency and change in gut microbiota composition induced by drinking hydrogen-dissolved AEW. The participants drank 500 mL of purified tap water or AEW every day for 2 weeks. In this study, drinking AEW did not drastically change gut microbiota, but it appeared to act on a specific bacterial species. Drinking AEW was confirmed to cause an increase in Bifidobacterium. The AEW group also saw stool consistency significantly converge to Bristol stool scale Type 4 ("normal"). Therefore, it is highly likely that the gut microbiota will be changed by drinking AEW. This study was retrospectively registered in University Hospital Medical Information Network (UMIN) Clinical Trials Registry (UMIN ID: UMIN000039507) on February 18, 2020, and was approved by the Ethics Committee of University of Yamanashi (approval No. H30-25) on January 9, 2018.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de4fbff8bf4414468ec8215e61483e6 https://doi.org/10.4103/2045-9912.318858 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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