The value of cytoplasmic Y-box-binding protein 1 as a prognostic marker for breast cancer in Korean
| Autor: | Sun Hee Sung, Woosung Lim, Byung In Moon, Anbok Lee, Heejung Park, Juhyun Woo, Ju Young Seoh |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
0301 basic medicine Oncology CA15-3 Cytoplasm medicine.medical_specialty Breast Neoplasms Kaplan-Meier Estimate Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer Asian People YBX1 protein Surgical oncology Transcription (biology) Internal medicine Biomarkers Tumor medicine Humans Radiology Nuclear Medicine and imaging Pharmacology (medical) Gene Breast neoplasm General Medicine Middle Aged Y box binding protein 1 Prognosis medicine.disease 030104 developmental biology chemistry Radiology Nuclear Medicine and imaging 030220 oncology & carcinogenesis Cancer research Female Original Article Y-Box-Binding Protein 1 DNA Human |
| Zdroj: | Breast Cancer (Tokyo, Japan) |
| ISSN: | 1340-6868 |
| DOI: | 10.1007/s12282-015-0625-8 |
| Popis: | Background The human Y-box-binding protein 1 (YB-1) is a member of the DNA/RNA-binding family of proteins that regulates transcription and translation of genes. Previous studies suggest that YB-1 may have an oncogenic role in various cancers. In this study, we evaluate the prognostic value of cytoplasmic YB-1 with respect to breast cancer. Methods Immunohistochemical staining study was performed with YB-1 using tissue block from 233 patients with invasive ductal carcinoma. Patients were divided into two groups according to expression of cytoplasmic YB-1 in tumor cell (high versus low). The relationship between the expression of YB-1, clinicopathological characteristics and breast cancer prognosis was analyzed. Results Hormone receptor negativity, worse histologic and nuclear grade, high tumor stage, lymphovascular invasion and high Ki67 (≥14 %) were related with the increased expression of cytoplasmic YB-1 in tumor cell (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|