Modulation of experimental osteoporosis in rats by the antioxidant beverage effective microorganism-X (EM-X)
| Autor: | Yunfei Ling, Teruo Higa, Okezie I. Aruoma, Bin Ke, Wenying Qiu, Yuanyuan Xu, Zenglu Xu |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Bone density Ovariectomy Osteoporosis Antioxidants Rats Sprague-Dawley Bone Density Internal medicine medicine Animals Femur Pharmacology Estradiol Plant Extracts business.industry Increased Bone Density General Medicine Bone fracture medicine.disease Rats Disease Models Animal medicine.anatomical_structure Endocrinology Epiphysis Ovariectomized rat Female Photosynthetic bacteria business Epiphyses |
| Zdroj: | Biomedicine & Pharmacotherapy. 63:114-119 |
| ISSN: | 0753-3322 |
| Popis: | Osteoporosis is a disease of aging associated with bone loss that often occurs without symptoms until microarchitectural deterioration becomes so significant that bone fracture occurs. The effective microorganism-X (EM-X) is an antioxidant beverage derived from ferment of unpolished rice, sea weeds and papaya with effective microorganisms of lactic acid bacteria, yeast and photosynthetic bacteria (containing minerals, alpha-tocopherol, lycopene, ubiquinone, saponin and flavonoids). The levels of serum estradiol (E(2)) and the bone density of the middle and epiphysis of femurs were assessed in order to determine the effect of EM-X on osteoporosis in ovariectomized rat (an animal model of postmenopausal osteoporosis). EM-X (1 ml/rat/day) was initially administrated by gavage to rats which were then allowed to consume 10% (v/v) EM-X in water freely for 3 months. There was no statistical significance of E(2) level between sham operation group and control group, indicating that sham operation did not affect E(2) level. However, the E(2) levels in the ovariectomized rats tended to increase after treatment of EM-X for 3 months. The bone density of the middle and epiphysis of femur in both sham operation and ovariectomy group decreased with time. Rats receiving EM-X for 3 months after sham operation or ovariectomy had increased bone density of the middle of femur that was statistically significant (P0.01 and P0.05). The bone density of the epiphysis of femur in both sham operation and ovariectomy group were significantly increased, an outcome highly suggestive of the beneficial effects of EM-X on bone density of the middle and the epiphysis of femur in the rats with or without ovariectomy. |
| Databáze: | OpenAIRE |
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