Apathy Is Associated With Increased Amyloid Burden in Mild Cognitive Impairment
| Autor: | Rebecca E. Amariglio, Gad A. Marshall, Christopher Gidicsin, Dorene M. Rentz, J. Alex Becker, Natacha Lorius, Nancy J. Donovan, Reisa A. Sperling, Lesley C. Pepin, Keith A. Johnson, Jacqueline E. Maye |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Oncology Amyloid medicine.medical_specialty Apathy Disease Article chemistry.chemical_compound Fluorodeoxyglucose F18 Functional neuroimaging Internal medicine mental disorders medicine Humans Dementia Cognitive Dysfunction Cognitive impairment Psychiatry Aged Aged 80 and over Cerebral Cortex Aniline Compounds medicine.diagnostic_test Functional Neuroimaging Middle Aged medicine.disease Thiazoles Psychiatry and Mental health chemistry Positron emission tomography Positron-Emission Tomography Female Neurology (clinical) Radiopharmaceuticals medicine.symptom Psychology Pittsburgh compound B |
| Zdroj: | The Journal of Neuropsychiatry and Clinical Neurosciences. 25:302-307 |
| ISSN: | 1545-7222 0895-0172 |
| DOI: | 10.1176/appi.neuropsych.12060156 |
| Popis: | Apathy is the most common neuropsychiatric symptom in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia. The authors sought to determine whether apathy is associated with cortical amyloid burden, as measured by Pittsburgh Compound B (PiB) positron emission tomography (PET), and regional hypometabolism, measured by 18F-fluorodeoxyglocuse (FDG) PET in MCI. The authors found a significant association between increased apathy (lower Apathy Evaluation Scale score) and greater cortical PiB retention independent of age, but no significant association between apathy and regional FDG metabolism. These results suggest that increased apathy is associated with greater amyloid burden but not regional hypometabolism in MCI. |
| Databáze: | OpenAIRE |
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