Clinical significance of putative markers of cancer stem cells in gastric cancer: A retrospective cohort study
| Autor: | Yi-Gao Wang, Xianming Mo, Kai Liu, Chang-Chun Li, Zong-Guang Zhou, Lian Xue, Jiankun Hu, Wei Wang, Wei-Han Zhang, Kun Yang, Xiao-Long Chen, Xin-Zu Chen, Lin-Yong Zhao, Jian-Ping Liu, Du He, Zheng-Hao Lu |
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| Rok vydání: | 2016 |
| Předmět: |
cancer stem cells
Male 0301 basic medicine Oncology Pathology markers Kaplan-Meier Estimate Cohort Studies chemistry.chemical_compound 0302 clinical medicine AC133 Antigen Neoplasm Metastasis Stage (cooking) Epithelial cell adhesion molecule Middle Aged Epithelial Cell Adhesion Molecule Prognosis Immunohistochemistry 030220 oncology & carcinogenesis embryonic structures Neoplastic Stem Cells Female biological phenomena cell phenomena and immunity Research Paper medicine.medical_specialty nomogram 03 medical and health sciences Stomach Neoplasms Cancer stem cell Internal medicine Biomarkers Tumor medicine Humans Clinical significance Aged Proportional Hazards Models Retrospective Studies business.industry gastric cancer SOXB1 Transcription Factors Cancer Retrospective cohort study Nomogram medicine.disease 030104 developmental biology chemistry Tumor progression Multivariate Analysis business Octamer Transcription Factor-3 |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Xiao-Long Chen 1, 2, * , Xin-Zu Chen 1, 2, * , Yi-Gao Wang 1, 2, * , Du He 3 , Zheng-Hao Lu 1, 2 , Kai Liu 1, 2 , Wei-Han Zhang 1, 2 , Wei Wang 1, 2 , Chang-Chun Li 1, 2 , Lian Xue 1, 2 , Lin-Yong Zhao 1, 2 , Kun Yang 1, 2 , Jian-Ping Liu 3 , Zong-Guang Zhou 1, 4 , Jian-Kun Hu 1, 2 , Xian-Ming Mo 5 1 Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China 2 Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China 3 Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China 4 Institute of Digestive Surgery, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China 5 Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China * These authors have contributed equally to this work Correspondence to: Jian-Kun Hu, email: hujkwch@126.com Keywords: gastric cancer, cancer stem cells, markers, prognosis, nomogram Received: December 22, 2015 Accepted: August 08, 2016 Published: August 19, 2016 ABSTRACT Cancer stem cells (CSCs) are thought as the source of tumor maintaining and many CSCs markers have been identified. Regarding the heterogeneity in gastric cancer (GC), TNM stage is not enough to accurately predict the prognosis. The aim of this study was to investigate the clinical significance of CSCs markers (Lgr5, Oct4, CD133, EpCAM, CD54 and Sox2) and establish a new model based on these markers to accurately predict prognosis of GC. We retrospectively enrolled 377 GC tissues from January 2006 to October 2012 to perform immunohistochemistry (IHC), and 93 pairs of GC tissues and corresponding adjacent normal gastric tissues to perform quantitative PCR (qPCR) from December 2011 to October 2012. The clinicopathological and follow-up characteristics were collected. In IHC, Oct4, CD133 and EpCAM were independently related to tumor progression, while Sox2 were associated with well or moderate differentiation (all p |
| Databáze: | OpenAIRE |
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