Does rapid intraoperative parathyroid hormone analysis predict cure in patients undergoing surgery for primary hyperparathyroidism? A prospective study
| Autor: | F. S. Nilsen, M. Heidemann, S. J. Karlsen, E. Haug |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Parathyroidectomy
Adult Male Technetium Tc 99m Sestamibi medicine.medical_specialty medicine.medical_treatment Parathyroid hormone Scintigraphy 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Monitoring Intraoperative Medicine Humans In patient Prospective Studies Prospective cohort study Radionuclide Imaging Pathological Aged Aged 80 and over Hyperparathyroidism medicine.diagnostic_test business.industry Middle Aged medicine.disease Surgery Parathyroid Hormone 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female Radiopharmaceuticals business Primary hyperparathyroidism |
| Zdroj: | Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society. 95(1) |
| ISSN: | 1457-4969 |
| Popis: | Background and Aims: Preoperative 99mTc-sestamibi scintigraphy is used by many surgeons to identify the anatomical location of pathological parathyroid glands in patients undergoing surgical treatment for hyperparathyroidism. However, false negative results do occur. It has been suggested that intraoperative parathyroid hormone (PTH) analysis may enhance the possibility of performing successful focused, unilateral neck surgery in these patients. This study aimed to evaluate whether an adequate fall in intraoperative parathyroid hormone values predicts the removal of all hyperfunctioning parathyroid tissue and postoperative normocalcemia. Material and Methods: One hundred consecutive patients undergoing surgery for hyperparathyroidism had preoperative 99mTc-sestamibi scintigraphy and intraoperative parathyroid hormone (PTH) analysis. A fall in intraoperative PTH value by more than 50% of baseline value ended the procedure. This prospective study presents the clinical and biochemical results. Results: The overall sensitivity of the 99mTc-sestamib scintigraphy was 88% and for single adenomas 95%. The scintigraphy failed to detect the correct pathology in all cases with multiglandular disease (7 patients). A fall in intraoperative PTH value by more than 50% of baseline value was achieved in all patients. The combination of intraoperative PTH analysis and 99mTc-sestamibi scintigraphy enabled us to limit the operation to a focused, unilateral operation in 87 of the 100 patients. All patients were normocalcemic postoperatively. Conclusions: A fall in intraoperative PTH value more than 50 % of baseline value seems to predict postoperative normocalcemia and the removal of all hyperfunctioning parathyroid tissue. Bilateral neck exploration is avoided in the majority of patients. |
| Databáze: | OpenAIRE |
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