A three-year follow-up study of patients with the respiratory subtype of panic disorder after treatment with clonazepam
| Autor: | Walter A. Zin, Rafael C. Freire, Fabiana L. Lopes, Antonio Egidio Nardi, Marco A. Mezzasalma, Alexandre Martins Valença, Isabella Nascimento, André Barciela Veras, Marcio Versiani |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Clonazepam Drug Administration Schedule Internal medicine medicine Humans Prospective Studies Family history Respiratory system GABA Modulators Biological Psychiatry Benzodiazepine Dose-Response Relationship Drug Respiration Panic disorder Therapeutic effect Panic Middle Aged medicine.disease Psychiatry and Mental health Treatment Outcome Anesthesia Panic Disorder Anticonvulsants Female medicine.symptom Psychology Anxiety disorder Follow-Up Studies medicine.drug |
| Zdroj: | Psychiatry Research. 137:61-70 |
| ISSN: | 0165-1781 |
| Popis: | The demographic, clinical and therapeutic features of the respiratory subtype of panic disorder (PD) versus the non-respiratory subtype were studied in a prospective design. Sixty-seven PD outpatients (DSM-IV), who had previously been categorized into respiratory ( n =35) and non-respiratory ( n =32) subgroups, were openly treated with clonazepam for a 3-year period. The principal measure of efficacy was the number of panic attacks, obtained from the Sheehan Panic and Anticipatory Anxiety Scale. In the first 8 weeks of treatment (acute phase), the respiratory subtype group had a significantly faster response to clonazepam. During the follow-up (weeks 12-156), the two subgroups did not differ significantly in the number of panic attacks experienced from baseline to end point. Patients in the respiratory subtype were characterized by a later onset of disorder and a family history of PD. Patients in the non-respiratory subgroup had a significantly higher number of past depressive episodes than those in the respiratory subgroup. The respiratory subgroup had a faster response after 8 weeks of treatment and an equivalent response in the 3-year follow-up period. Clonazepam had a sustained therapeutic effect over the entire treatment period. |
| Databáze: | OpenAIRE |
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