Whole-body heat stress and exercise stimulate the appearance of platelet microvesicles in plasma with limited influence of vascular shear stress

Autor: Steven J. Trangmar, Mark Rakobowchuk, Eurico Nestor Wilhelm, Kameljit K. Kalsi, José González-Alonso, Scott T Chiesa
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Hot Temperature
Physiology
030204 cardiovascular system & hematology
0302 clinical medicine
Cell-Derived Microparticles
Platelet
Original Research
microparticles
Endurance and Performance
Cycling
Heat stress
Passive heating
Femoral Artery
Radial Artery
Christian ministry
Whole body
Shear Strength
Adult
Blood Platelets
medicine.medical_specialty
dynamic knee extensor exercise
Skeletal Muscle
B100
passive heating
Heat Stress Disorders
Thermoregulation
shear stress
03 medical and health sciences
Young Adult
Stress
Physiological
Physiology (medical)
medicine
Shear stress
Humans
Leg
business.industry
Hemodynamics
Endothelial Cells
1103 Clinical Sciences
0606 Physiology
C600
Microvesicles
Circulation
030104 developmental biology
1116 Medical Physiology
Physical therapy
Cellular Physiology
business
Zdroj: Physiological Reports
University of Roehampton-PURE
ISSN: 2051-817X
Popis: Intense, large muscle mass exercise increases circulating microvesicles, but our understanding of microvesicle dynamics and mechanisms inducing their release remains limited. However, increased vascular shear stress is generally thought to be involved. Here, we manipulated exercise‐independent and exercise‐dependent shear stress using systemic heat stress with localized single‐leg cooling (low shear) followed by single‐leg knee extensor exercise with the cooled or heated leg (Study 1, n = 8) and whole‐body passive heat stress followed by cycling (Study 2, n = 8). We quantified femoral artery shear rates (SRs) and arterial and venous platelet microvesicles (PMV–CD41+) and endothelial microvesicles (EMV–CD62E+). In Study 1, mild passive heat stress while one leg remained cooled did not affect [microvesicle] (P ≥ 0.05). Single‐leg knee extensor exercise increased active leg SRs by ~12‐fold and increased arterial and venous [PMVs] by two‐ to threefold, even in the nonexercising contralateral leg (P
Databáze: OpenAIRE
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